Trial reportNeonatology2015
Prediction of respiratory outcome in extremely low gestational age infants.
Trial report in Neonatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03014453 (Gastroesophageal Reflux Poses a Potential Risk for Late Complications of BPD), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Gastroesophageal Reflux Poses a Potential Risk for Late Complications of BPD: A Prospective Study
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Porcine vs bovine surfactant therapy for preterm neonates with RDS: systematic review with biological plausibility and pragmatic meta-analysis of respiratory outcomes.Respiratory research · 2019Pooled it
- The role of recombinant human CC10 in the prevention of chronic pulmonary insufficiency of prematurity.Pediatric research · 2019Trial
- Bronchopulmonary Dysplasia and Perinatal Characteristics Predict 1-Year Respiratory Outcomes in Newborns Born at Extremely Low Gestational Age: A Prospective Cohort Study.The Journal of pediatrics · 2017Trial
- Lung Ultrasonography Scores in Preterm Infants and Respiratory Outcomes at Age 2 Years.JAMA network open · 2024Article
- Prematurity-associated wheeze: current knowledge and opportunities for further investigation.Pediatric research · 2023Review
- Article
- Differences in clinical and laboratory biomarkers for short and long-term respiratory outcomes in preterm neonates.Pediatric pulmonology · 2021Article
- Advancing Therapeutic Development for Pulmonary Morbidities Associated with Preterm Birth.Therapeutic innovation & regulatory science · 2020Article
- Role of Genetic Susceptibility in the Development of Bronchopulmonary Dysplasia.The Journal of pediatrics · 2018Article
- Relevance of clinical features in the prognosis of bronchopulmonary dysplasia in premature infants.Experimental and therapeutic medicine · 2017Article
- Stem Cell Therapy for Neonatal Disorders: Prospects and Challenges.Yonsei medical journal · 2017Review
- Blood Cytokine Profiles Associated with Distinct Patterns of Bronchopulmonary Dysplasia among Extremely Low Birth Weight Infants.The Journal of pediatrics · 2016Observational
- Updates on Functional Characterization of Bronchopulmonary Dysplasia - The Contribution of Lung Function Testing.Frontiers in medicine · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundBronchopulmonary dysplasia (BPD) is a commonly used outcome for randomized neonatal trials.
objectivesThe aim of the present study was to determine whether a diagnosis of BPD or respiratory morbidity (RM1 or RM2) at 12 months corrected age better predicted subsequent RM in extremely low gestational age infants (23-28 weeks of gestation).
methodsInitial analysis was undertaken in a development cohort of 76 infants who underwent pulmonary function tests (PFTs) at 12 months corrected age. Parents completed infant respiratory diaries 2 weeks before the PFTs. Analysis was then undertaken in a validation cohort of 227 infants whose parents completed a 4-week respiratory diary when their infant was 12 months corrected age. BPD at 28 days (BPD28d) and 36 weeks post-menstrual age (BPD36w), RM1 (≥3 days and/or nights of cough, wheeze, and/or medicine use) and RM2 (≥4 days and/or nights of cough, wheeze, and/or respiratory medicine use) each week for 2 weeks at 12 months corrected age were assessed with regard to prediction of respiratory outcomes at 24 months documented by respiratory health questionnaires.
resultsBPD28d and BPD36w were not significantly associated with any respiratory outcome. Areas under the receiver operating characteristic curves were significantly better for either definition of RM than BPD28d or BPD36w for all outcomes.
conclusionsRM documented by parental completed diaries at 12 months corrected age better predicted respiratory outcome at 24 months corrected age than BPD regardless of diagnostic criteria.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.