Evidence map›Paper›PMID 25765605›Full record

ReviewCurrent opinion in virology2015

Mechanisms of innate immune evasion in re-emerging RNA viruses.

Daphne Y Ma, Mehul S Suthar

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Unraveling the complexities of neurotropic virus infection and immune evasion.Microbiology and molecular biology reviews : MMBR · 2025
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  19. Coronavirus infections and immune responses.Journal of medical virology · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Daphne Y MaDepartment of Pediatrics and Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA 30329, USA; Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA 30329, USA.
Mehul S SutharDepartment of Pediatrics and Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA 30329, USA; Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA 30329, USA. Electronic address: msuthar@emory.edu.
Emory Healthcare · USEmory University · US

Funding

VACCINE INDUCED IMMUNITY IN THE YOUNG AND AGEDU19AI057266 · NIAID · EMORY UNIVERSITY · PI Rafi Ahmed · 2003 to 2026
$81.7M
West Nile Virus and host control of innate defensesU19AI083019 · NIAID · UNIVERSITY OF WASHINGTON · PI CLARK, EDWARD A · 2009 to 2018
$22.5M
Regulation of T cell immunity by the cytosolic RIG-I like receptorsR56AI110516 · NIAID · EMORY UNIVERSITY · PI SUTHAR, MEHUL SHAMAL · 2014 to 2014
$443k
Generation of MAVS conditional KO mice to study cell-type specific immunityR03AI109194 · NIAID · EMORY UNIVERSITY · PI SUTHAR, MEHUL SHAMAL · 2014 to 2015
$179k
NIAID NIH HHS 5U19AI057266NIAID NIH HHS R03 AI109194NIAID NIH HHS R03AI109194NIAID NIH HHS R56 AI110516NIAID NIH HHS R56AI110516NIAID NIH HHS U19 AI057266NIAID NIH HHS U19 AI083019NIAID NIH HHS U19AI083019
6 · The paper itself

Abstract

Recent outbreaks of Ebola, West Nile, Chikungunya, Middle Eastern Respiratory and other emerging/re-emerging RNA viruses continue to highlight the need to further understand the virus-host interactions that govern disease severity and infection outcome. As part of the early host antiviral defense, the innate immune system mediates pathogen recognition and initiation of potent antiviral programs that serve to limit virus replication, limit virus spread and activate adaptive immune responses. Concordantly, viral pathogens have evolved several strategies to counteract pathogen recognition and cell-intrinsic antiviral responses. In this review, we highlight the major mechanisms of innate immune evasion by emerging and re-emerging RNA viruses, focusing on pathogens that pose significant risk to public health.

Indexed as

Immune EvasionAnimalsCommunicable Diseases, EmergingHost-Pathogen InteractionsHumansImmunity, InnateInterferonsReceptors, Pattern RecognitionRNA VirusesRNA Virus InfectionsSignal TransductionVirus ReplicationInterferonsReceptors, Pattern Recognition

Identifiers

PMID25765605
PMCPMC4470747
OpenAlexW2031437584

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.