ArticleMolecular plant pathology2015
Transcriptome analysis highlights preformed defences and signalling pathways controlled by the prAe1 quantitative trait locus (QTL), conferring partial resistance to Aphanomyces euteiches in Medicago truncatula.
Article in Molecular plant pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 26 citations in OpenAlex.
- Aphanomyces euteiches causes disease in Lathyrus sativus with a globally diverse, polygenic resistance landscape.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Genetic mapping identifies QTL and candidate genes including Mendel's A gene controlling high levels of partial resistance to Fusarium avenaceum in Pea.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- QTL combinations associated with field partial resistance to Aphanomyces root rot in pea near-isogenic lines.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Article
- Transcriptomic analysis identifies candidate genes for Aphanomyces root rot disease resistance in pea.BMC plant biology · 2024Article
- The mycoparasiteFrontiers in plant science · 2023Article
- Research Progress and Prospect of Alfalfa Resistance to Pathogens and Pests.Plants (Basel, Switzerland) · 2022Review
- Root rot a silent alfalfa killer in China: Distribution, fungal, and oomycete pathogens, impact of climatic factors and its management.Frontiers in microbiology · 2022Review
- Dissecting the Genetic Architecture of Aphanomyces Root Rot Resistance in Lentil by QTL Mapping and Genome-Wide Association Study.International journal of molecular sciences · 2020Article
- Medicago TERPENE SYNTHASE 10 Is Involved in Defense Against an Oomycete Root Pathogen.Plant physiology · 2019Article
- Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.BMC biology · 2018Article
- Nitrogen modulation of Medicago truncatula resistance to Aphanomyces euteiches depends on plant genotype.Molecular plant pathology · 2018Article
- Is there genetic variation in mycorrhization ofPeerJ · 2017Article
- Article
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7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
To gain an insight into the molecular mechanisms of quantitative disease resistance in Medicago truncatula to the root-infecting oomycete Aphanomyces euteiches, we selected two near-isogenic lines (NILs), NR and NS, partially resistant and susceptible, respectively, differing in the allelic state of the quantitative resistance locus (QRL) prAe1 (partially resistant to A. euteiches 1). Complementary molecular and cytological phenotyping methods showed that prAe1 alone confers quantitative resistance to A. euteiches. Root and stem tissues were colonized in NS plants and 80% of NS plants died by 21 days post-inoculation (dpi). In contrast, A. euteiches mycelium was restricted to the root cortex and the spread of symptoms was arrested in aerial parts of NR plants. A transcriptome analysis performed at 0, 1 and 6 dpi identified 1198 differentially expressed genes (DEGs) between NR and NS lines. More than 87% of the DEGs were significantly more expressed in NR. The highest number of DEGs was found in control conditions, with 723 genes over-expressed in NR versus 85 in NS. Genes belonging to secondary metabolism, pathogenesis-related (PR) proteins and kinases were significantly enriched. The significant role of the flavonoid pathway in resistance was corroborated by the detection of larger amounts of flavonoids in NR roots and the inhibition of A. euteiches zoospore germination by 2'-O-methyl-isoliquiritigenin, a compound synthesized by enzymes specifically induced in NR. Our study revealed that prAe1-dependent resistance relies mainly on the constitutive expression of defence-related pathways and signalling elements, which can be re-amplified in later time points of the infection.
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