Evidence map›Paper›PMID 25765257›Full record

ArticleNeuroImage2015

Online fronto-cortical control of simple and attention-demanding locomotion in humans.

Roee Holtzer, Jeannette R Mahoney, Meltem Izzetoglu, Cuiling Wang, Sarah England, Joe Verghese

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04934956 (Locomotor Adaptability for Community Mobility of Older Adults), which is not on this map. Cited by 124 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04934956 nacompletednot on this mapstarted 2021, after this paper: background citation

Locomotor Adaptability for Community Mobility of Older Adults: The Role of Gait Automaticity

TypeinterventionalSponsorUniversity of PittsburghRan2021 to 2025Enrolled44ConditionsCommunity Mobility of Older Adults, Locomotor Adaptability, Gait AutomaticityArmsSplit-belt walking, Multiple transitions between split-belt and tied-belt walking
3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  19. Evaluation of Neural, Systemic and Extracerebral Activations During Active Walking Tasks in Older Adults Using fNIRS.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2025
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64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Roee HoltzerDepartment of Neurology, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA; Ferkauf Graduate School of Psychology of Yeshiva University, Bronx, NY, USA. Electronic address: roee.holtzer@einstein.yu.edu.
Jeannette R MahoneyDepartment of Neurology, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA.
Meltem IzzetogluDrexel University School of Biomedical Engineering, Philadelphia, PA, USA.
Cuiling WangDepartment of Epidemiology, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA.
Sarah EnglandFerkauf Graduate School of Psychology of Yeshiva University, Bronx, NY, USA.
Joe VergheseDepartment of Neurology, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA; Department of Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA.

Funding

Central Control of Mobility in AgingR01AG036921 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI HOLTZER, ROEE · 2011 to 2015
$3.3M
NIA NIH HHS R01 AG036921NIA NIH HHS R01AG036921
6 · The paper itself

Abstract

Knowledge of online functional brain mechanisms of locomotion is scarce due to technical limitations of traditional neuroimaging methods. Using functional Near Infrared Spectroscopy (fNIRS) we evaluated task-related changes in oxygenated hemoglobin levels (HbO2) in real-time over the pre-frontal-cortex (PFC) regions during simple (Normal Walk; NW) and attention-demanding (Walking While Talking; WWT) locomotion tasks in a large cohort of non-demented older adults. Results revealed that the assessment of task-related changes in HbO2 was internally consistent. Imposing greater demands on the attention system during locomotion resulted in robust bilateral PFC increases in HbO2 levels during WWT compared to NW and the cognitive interference tasks. Elevated PFC oxygenation levels were maintained throughout the course of WWT but not during the NW condition. Increased oxygenation levels in the PFC were related to greater stride length and better cognitive performance but not to faster gait velocity in WWT. These findings elucidate online brain mechanisms of locomotion, and confer significant implications for risk assessment and intervention for major mobility outcomes.

Indexed as

AgedAged, 80 and overAttentionCognitionCohort StudiesFemaleFrontal LobeGaitHemodynamicsHemoglobinsHumansLocomotionLongitudinal StudiesMaleMiddle AgedNeuropsychological TestsHemoglobins

Identifiers

PMID25765257
PMCPMC4408246

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.