ArticleProceedings of the Japan Academy. Series B, Physical and biological sciences2015
Ca2+ and cAMP regulations of microtubule sliding in hyperactivated motility of bull spermatozoa.
Article in Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 11 citations in OpenAlex.
- Bull Sperm Capacitation Is Accompanied by Redox Modifications of Proteins.International journal of molecular sciences · 2021Article
- Intracellular Ca2+ threshold reversibly switches flagellar beat off and on.Biology of reproduction · 2018Article
- Self-Sustained Oscillatory Sliding Movement of Doublet Microtubules and Flagellar Bend Formation.PloS one · 2016Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To reach and fertilize the egg, mammalian spermatozoa change their flagellar movement in the female reproductive tract, named hyperactivation. The biochemical analyses of the hyperactivated movement using demembranated spermatozoa defined the factors inducing this peculiar movement; namely, large asymmetrical flagellar movement observed in the early stage of the hyperactivation was induced with a high Ca(2+) concentration while large symmetrical flagellar movement in the late stage of the hyperactivation was generated with low Ca(2+) and high cAMP concentrations. Under these conditions, the microtubule sliding of bull sperm flagella was investigated by disintegrating the sperm flagella with MgATP(2-) after extracting their plasma membrane and mitochondria. The large asymmetrical flagellar movement was caused by a long sliding displacement of a fiber of the doublet microtubules. On the other hand, the large symmetrical flagellar movement was generated by a large amount of microtubule sliding by many doublet microtubules.
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Registered trials
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