Evidence map›Paper›PMID 25764519›Full record

ReviewProteomics. Clinical applications2015

Urinary biomarkers of kidney diseases in HIV-infected children.

Sofia Perazzo, Ángel A Soler-García, Yetrib Hathout, Jharna R Das, Patricio E Ray

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Proteomics. Clinical applications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sofia PerazzoCenter for Genetic Medicine Research, Children's National Medical Center, The George Washington University, Washington, DC, USA.
Ángel A Soler-GarcíaCenter for Genetic Medicine Research, Children's National Medical Center, The George Washington University, Washington, DC, USA.
Yetrib HathoutCenter for Genetic Medicine Research, Children's National Medical Center, The George Washington University, Washington, DC, USA.
Jharna R DasCenter for Genetic Medicine Research, Children's National Medical Center, The George Washington University, Washington, DC, USA.
Patricio E RayCenter for Genetic Medicine Research, Children's National Medical Center, The George Washington University, Washington, DC, USA.
George Washington University · USChildren's National · US

Funding

Role of bFGF low affinity receptors in childhood HIVANR01DK049419 · NIDDK · UNIVERSITY OF VIRGINIA · PI PATRICIO E. RAY · 1994 to 2026
$7.4M
Pathogenesis of HIV-HUS in childrenR01HL055605 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI RAY, PATRICIO E. · 1995 to 2012
$4.3M
Preclinical dosing optimization: Dosing schedule, tissueU54HD071601 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI JOSE, PEDRO A. · 2011 to 2015
$4.0M
Role of cytokines and APOL-1 in the pathogenesis of childhood HIV associated nephrologyR01DK103564 · NIDDK · UNIVERSITY OF VIRGINIA · PI RAY, PATRICIO E. · 2014 to 2023
$3.0M
Pathogenesis of chronic renal injury and hypertension in HIV-infected childrenR01DK108368 · NIDDK · UNIVERSITY OF VIRGINIA · PI RAY, PATRICIO E. · 2015 to 2019
$1.5M
NHLBI NIH HHS HL55605NHLBI NIH HHS R01 HL055605NICHD NIH HHS U54 HD071601NICHD NIH HHS U54HD071601NIDDK NIH HHS DK103564NIDDK NIH HHS DK49419NIDDK NIH HHS R01 DK049419NIDDK NIH HHS R01 DK103564NIDDK NIH HHS R01 DK108368
6 · The paper itself

Abstract

A significant number of children infected with the human immunodeficiency virus 1 (HIV-1) virus all over the world are at risk of developing renal diseases that could have a significant impact on their treatment and quality of life. It is necessary to identify children undergoing the early stages of these renal diseases, as well as the potential renal toxicity that could be caused by antiretroviral drugs, in order to prevent the development of cardiovascular complications and chronic renal failure. This article describes the most common renal diseases seen in HIV-infected children, as well as the value and limitations of the clinical markers that are currently being used to monitor their renal function and histological damage in a noninvasive manner. In addition, we discuss the progress made during the last 10 years in the discovery and validation of new renal biomarkers for HIV-infected children and young adults. Although significant progress has been made during the early phases of the biomarkers discovery, more work remains to be done to validate the new biomarkers in a large number of patients. The future looks promising, however, the new knowledge needs to be integrated and validated in the context of the clinical environment where these children are living.

Indexed as

AnimalsBiomarkersChild, PreschoolHIV InfectionsHumansKidney DiseasesBiomarkersAcute kidney injuryHemolytic uremic syndromeHIV-associated nephropathyProteinuriaRenal urinary biomarkers

Identifiers

PMID25764519
PMCPMC4530778
OpenAlexW2046767404

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.