Evidence map›Paper›PMID 25764221›Full record

ArticleTranscription2014

A matter of access. Nucleosome disassembly from gene promoters is the central goal of transcriptional activators.

Zheng Hu, Kaifu Chen, Wei Li, Jessica K Tyler

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transcription, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Zheng Hua Department of Biochemistry and Molecular Biology; The University of Texas MD Anderson Cancer Center; Houston, TX USA.
Kaifu Chen
Wei Li
Jessica K Tyler
The University of Texas MD Anderson Cancer Center · USBaylor College of Medicine · USDan L Duncan Comprehensive Cancer Center

Funding

Chromatin's Role in Repair of Radiation-induced Damage.R01CA095641 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI TYLER, JESSICA K · 2002 to 2023
$5.2M
Chromatin Assembly, Structure and FunctionR01GM064475 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI TYLER, JESSICA K · 2002 to 2019
$4.4M
Computational and Experimental Modeling of Epigenetic DNA MethylationR01HG007538 · NHGRI · UNIVERSITY OF CALIFORNIA-IRVINE · PI LI, WEI · 2014 to 2018
$1.9M
NCI NIH HHS R01 CA095641NCI NIH HHS R01CA95641NHGRI NIH HHS R01 HG007538NHGRI NIH HHS R01HG007538NIGMS NIH HHS R01 GM064475NIGMS NIH HHS R01GM64475
6 · The paper itself

Abstract

The mechanism whereby transcriptional activators facilitate transcription activation has been debated. Our recent genome-wide profiling of gene expression during aging, where nucleosomes are depleted, indicates that the function of seemingly all transcriptional activators is to trigger nucleosome disassembly from promoters to allow the general transcription machinery access to the DNA.

Indexed as

Promoter Regions, GeneticTranscriptional ActivationDNA-Binding ProteinsFungal ProteinsNucleosomesYeastsDNA-Binding ProteinsFungal ProteinsNucleosomesaginghistonesnucleosomestranscriptionyeast

Identifiers

PMID25764221
PMCPMC4215176
OpenAlexW2329015469

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.