Evidence map›Paper›PMID 25764158›Full record

ArticleInternational journal of molecular sciences2015

A polymorphism at the translation start site of the vitamin D receptor gene is associated with the response to anti-osteoporotic therapy in postmenopausal women from southern Italy.

Valeria Conti, Giusy Russomanno, Graziamaria Corbi, Giuseppe Toro, Vittorio Simeon, Walter Filippelli, Nicola Ferrara, Michela Grimaldi, Valeria D'Argenio, Nicola Maffulli and 1 more

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In one paragraph

Article in International journal of molecular sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 13 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 13 syntheses or guidelines pooled it, 133 citations in OpenAlex.

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41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Valeria ContiDepartment of Medicine and Surgery, University of Salerno, Baronissi 84081, Italy. vconti@unisa.it.
Giusy RussomannoDoctoral School of Translational and Clinical Medicine, University of Salerno, Baronissi 84081, Italy. grussomanno@unisa.it.
Graziamaria CorbiDepartment of Medicine and Health Sciences, University of Molise, Campobasso 86100, Italy. graziamaria.corbi@unimol.it.
Giuseppe ToroUnit of Orthopaedics and Traumatology, "Martiri del Villa Malta" Hospital, Sarno 84087, Italy. giuseppe.toro@gmail.com.
Vittorio SimeonLaboratory of Pre-clinical and Translational Research, Reference Cancer Center of Basilicata, Scientific Institute of Hospitalization and Treatment, Rionero in Vulture 85028, Italy. vittoriosimeon@gmail.com.
Walter FilippelliDepartment of Studies for Institutions and Territorial Systems, University "Parthenope" of Naples, Naples 80133, Italy. walter.filippelli@uniparthenope.it.
Nicola FerraraDepartment of Medical Translational Sciences, University of Naples Federico II, Naples 80131, Italy. nicola.ferrara@unina.it.
Michela GrimaldiDepartment of Medicine and Surgery, University of Salerno, Baronissi 84081, Italy.
Valeria D'ArgenioDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Naples 80131, Italy. dargenio@ceinge.unina.it.
Nicola MaffulliDepartment of Musculoskeletal Disorders, Faculty of Medicine and Surgery, University of Salerno, Baronissi 84081, Italy. nmaffulli@unisa.it.
Amelia FilippelliDepartment of Medicine and Surgery, University of Salerno, Baronissi 84081, Italy. afilippelli@unisa.it.
University of Salerno · ITCentro di Riferimento Oncologico della Basilicata · ITInstitute for Scientific Interchange · ITParthenope University of Naples · ITUniversity of Molise · ITUniversity of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study investigated the effect of two single nucleotide polymorphisms (SNPs) of the vitamin D receptor (VDR) gene, rs1544410 A/G and rs2228570 C/T, in modulating bone mineral density (BMD) and the response to treatment with bisphosphonates or strontium ranelate in postmenopausal osteoporosis (PMO). Four hundred eighteen postmenopausal women from Southern Italy treated with bisphosphonates or strontium ranelate for three years were enrolled and stratified according to their genotype. Changes in BMD were expressed as the delta t-score (Δt-score). Allelic frequencies for rs1544410 A/GSNP were 11.2% AA, 50.0% GA and 38.8% GG; for rs2228570 C/TSNP were 54.8% CC, 39.5% TC and 5.7% TT. TT carriers showed a lower t-score than TC and CC (both p < 0.02) genotypes and were more responsive to the therapy when compared to both TC (p < 0.02) and CC (p < 0.05) carriers. Specifically, TT carriers receiving alendronate demonstrated a significant improvement of the Δt-score compared to TC and CC (both p < 0.0001) carriers. After adjustment for confounders, the Δt-score showed evidence of a statistically significant positive association with TT in all treatments considered. Therapy response was independent of rs1544410 A/G SNP; instead, rs2228570 C/TSNP was associated with a better response to antiresorptive treatment, thus suggesting that the therapy for PMO should be personalized.

Indexed as

Polymorphism, Single NucleotideAlendronateBone Density Conservation AgentsCase-Control StudiesFemaleHumansItalyMiddle AgedOsteoporosisPostmenopauseReceptors, CalcitriolThiophenesTreatment OutcomeAlendronateBone Density Conservation AgentsReceptors, Calcitriolstrontium ranelateThiophenesVDR protein, human

Identifiers

PMID25764158
PMCPMC4394486
OpenAlexW2056780609

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.