ArticleThe Pediatric infectious disease journal2015
Seroprevalence of pertussis in the Gambia: evidence for continued circulation of bordetella pertussis despite high vaccination rates.
Article in The Pediatric infectious disease journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- Is Pertussis Infection Neglected in China? Evidence from a Seroepidemiology Survey in Zhejiang, an Eastern Province of China.PloS one · 2016Trial
- Seroepidemiological Assessment ofHealth care science · 2025Article
- The seroepidemiology of immunoglobulin G antibodies against pertussis toxin and filamentous hemagglutinin in the east of China during the COVID-19 pandemic.Human vaccines & immunotherapeutics · 2024Article
- Profile: The Kenya Multi-Site Serosurveillance (KEMIS) collaboration.Gates open research · 2024Article
- Article
- Seroprevalence of Pertussis in Adults at Childbearing Age Pre- and Post- COVID-19 in Beijing, China.Vaccines · 2022Article
- Bordetella pertussis in School-Age Children, Adolescents, and Adults: A Systematic Review of Epidemiology, Burden, and Mortality in Africa.Infectious diseases and therapy · 2021Review
- Seroprevalence of pertussis in Madagascar and implications for vaccination.Epidemiology and infection · 2020Article
- Article
- Pertussis outbreak investigation in Janamora district, Amhara Regional State, Ethiopia: a case-control study.The Pan African medical journal · 2019Article
- Outbreak of suspected pertussis in Kaltungo, Gombe State, Northern Nigeria, 2015: the role of sub-optimum routine immunization coverage.The Pan African medical journal · 2019Article
- IL-17-dependent SIgA-mediated protection against nasal Bordetella pertussis infection by live attenuated BPZE1 vaccine.Mucosal immunology · 2018Article
- The Role of Mucosal Immunity in Pertussis.Frontiers in immunology · 2018Review
- Seroprevalence of Bordetella pertussis antibodies in adults in Hungary: results of an epidemiological cross-sectional study.BMC infectious diseases · 2017Article
- Immune persistence after pertussis vaccination.Human vaccines & immunotherapeutics · 2017Review
- A high seroprevalence of antibodies to pertussis toxin among Japanese adults: Qualitative and quantitative analyses.PloS one · 2017Article
- Bordetella pertussis Infection in South African HIV-Infected and HIV-Uninfected Mother-Infant Dyads: A Longitudinal Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Article
- Influence of Population Demography and Immunization History on the Impact of an Antenatal Pertussis Program.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Article
- Morbidity and Mortality Due to Bordetella pertussis: A Significant Pathogen in West Africa?Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Review
- Assessing the Evidence for Maternal Pertussis Immunization: A Report From the Bill & Melinda Gates Foundation Symposium on Pertussis Infant Disease Burden in Low- and Lower-Middle-Income Countries.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Review
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Authors and funding
11 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundBordetella pertussis can cause severe respiratory disease and death in children. In recent years, large outbreaks have occurred in high-income countries; however, little is known about pertussis incidence in sub-Saharan Africa.
methodsWe evaluated antibody responses to pertussis toxin (Ptx) from individuals aged between 2 and 90 years in rural Gambia. IgG-Ptx was measured using luminex xMAP technology. IgG-Ptx geometric mean concentrations (GMC) and their 95% confidence intervals were calculated. The proportion seropositive (>20 EU/mL or ≥62.5 EU/mL) and GMCs were compared by age, sex, ethnic group, vaccination status, birth order and number of siblings per household using logistic and linear regression.
results76.3% had anti-Ptx levels <20 EU/mL, 17.5% had concentrations between 20 and 62.5 EU/mL, 4.4% had concentrations between 62.5 and 125 EU/mL and 1.8% had concentrations ≥125 EU/mL. The overall Ptx antibody GMC was 6.4 EU/mL (95% confidence interval: 5.8-6.9). Higher antibody concentrations were observed in older populations with evidence for an increase in infection risk with increasing age (1.9% yearly increase, 95% confidence interval: 1.3-2.5). No child under 6 years of age had GMC above 62.5 EU/mL but 29.5% had concentrations between 20 and 62.5 EU/mL.
conclusionsThese data provide evidence that B. pertussis is being transmitted within this population despite high vaccination coverage. Re-infection may occur implying that immunity from childhood vaccination may not be lifelong. In the absence of data on actual clinical cases of pertussis, seroprevalence studies remain valuable tools to assess the transmission dynamics of B. pertussis.
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