ArticleMicrobial ecology2015
Salivary Microbiota Associated with Immunoglobulin A Nephropathy.
Article in Microbial ecology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 57 citations in OpenAlex.
- Immune Cell Characteristics in a Gut-Kidney Axis-Induced Mouse Model of IgA Nephropathy: The Upregulated Dendritic Cells and Neutrophils.Journal of inflammation research · 2025Article
- Characteristics and function of the gut microbiota in patients with IgA nephropathy via metagenomic sequencing technology.Renal failure · 2024Article
- Lessons from IgA Nephropathy Models.International journal of molecular sciences · 2024Review
- Prediction of delayed graft function by early salivary microbiota following kidney transplantation.Applied microbiology and biotechnology · 2024Article
- The oral microbiome in autoimmune diseases: friend or foe?Journal of translational medicine · 2023Review
- Salivary microbiota analysis of patients with membranous nephropathy.Molecular medicine reports · 2022Article
- Title IgA Nephropathy and Oral Bacterial Species Related to Dental Caries and Periodontitis.International journal of molecular sciences · 2022Review
- Review
- Gut Microbes in Immunoglobulin A Nephropathy and Their Potential Therapeutic Applications.Frontiers in medicine · 2022Review
- The microbiome and IgA nephropathy.Seminars in immunopathology · 2021Review
- How will artificial intelligence and bioinformatics change our understanding of IgA Nephropathy in the next decade?Seminars in immunopathology · 2021Review
- Dysbiosis in the Salivary Microbiome Associated with IgA Nephropathy-A Japanese Cohort Study.Microbes and environments · 2021Article
- Identification of a novel interplay between intestinal bacteria and metabolites in Chinese patients with IgA nephropathy via integrated microbiome and metabolome approaches.Annals of translational medicine · 2021Article
- Potential Roles of Oral Microbiota in the Pathogenesis of Immunoglobin A Nephropathy.Frontiers in cellular and infection microbiology · 2021Article
- The Immunomodulatory Effect of the Gut Microbiota in Kidney Disease.Journal of immunology research · 2021Review
- Salivary microbiome in patients undergoing hemodialysis and its associations with the duration of the dialysis.BMC nephrology · 2020Article
- Comparative evaluation of peptidome and microbiota in different types of saliva samples.Annals of translational medicine · 2020Article
- Salivary microbial analysis of Chinese patients with immunoglobulin A nephropathy.Molecular medicine reports · 2019Article
- Microbiota issue in CKD: how promising are gut-targeted approaches?Journal of nephrology · 2019Review
- Microbiome-metabolome reveals the contribution of gut-kidney axis on kidney disease.Journal of translational medicine · 2019Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed at investigating the salivary microbiota of 28 patients affected by immunoglobulin A nephropathy (IgAN). Fourteen healthy volunteers (HC) were used as control. Compared to HC, the number of some cultivable bacteria groups (e.g., total anaerobes) significantly (P < 0.05) decreased in the salivary samples of IgAN patients. Total bacteria from salivary samples of IgAN patients and HC subjects were analyzed by pyrosequencing of 16S rRNA gene. Paired t test showed no significant (P > 0.05) differences of alpha-diversity parameters (OTU, ACE, Chao1, and Shannon index) between the salivary samples of HC and IgAN patients. The difference for the community structure was further analyzed using three phylogeny-based beta-diversity measures. Compared to HC, the ratio between Firmicutes/Proteobacteria markedly decreased in IgAN patients. Gemella haemolysins, Granulicatella adiacens, and Veillonella parvula were positively associated (P < 0.05) with HC. Within the phylum Bacteroidetes, Prevotella species (Prevotella nigrescens, Prevotella intermedia, Prevotella pallens, and Prevotella salivae) were the highest in HC. The only exception was for Prevotella aurantiaca. Compared to HC, the percentage of abundance of some species, belonging to Pasteurellaceae family (e.g., Haemophylus parainfluenzae), increased in IgAN patients. Fusobacteriaceae (Fusobacterium) and Corynebacterium sp. also differed between the salivary samples of HC and IgAN patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.