ArticlePlant signaling & behavior2014
Organelle import of proteins with dual targeting properties into mitochondria and chloroplasts takes place by the general import pathways.
Article in Plant signaling & behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- A viral protein targets mitochondria and chloroplasts by subverting general import pathways and specific receptors.Journal of virology · 2023Article
- GrpE is involved in mitochondrial function and is an effective target for RNAi-mediated pest and arbovirus control.Insect molecular biology · 2022Article
- Presequence translocase-associated motor subunits of the mitochondrial protein import apparatus are dual-targeted to mitochondria and plastids.Frontiers in plant science · 2022Article
- Proteomic and Bioinformatic Profiling of Transporters in Higher Plant Mitochondria.Biomolecules · 2020Review
- Rather rule than exception? How to evaluate the relevance of dual protein targeting to mitochondria and chloroplasts.Photosynthesis research · 2018Review
- The similarity between N-terminal targeting signals for protein import into different organelles and its evolutionary relevance.Frontiers in physiology · 2015Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As a consequence of the endosymbiotic gene transfer, most mitochondrial and chloroplastic proteins are nuclear encoded and synthesized in the cytosol as precursor proteins with transit peptides mediating transport to their subcellular destination. It is often assumed that these transit peptides are strictly monospecific for a single organelle. But in recent years more and more proteins have been identified which carry transit peptides that are capable of mediating transport into both mitochondria and chloroplasts. In a recent study we showed with a combination of in silico, in organello, and in vivo approaches that the frequency of such proteins is apparently much higher than usually anticipated.(1) Here we demonstrate with in organello competition experiments that the import of 2 of these dually targeted proteins (GrpE and EF-Tu) takes place by the same import pathways that are used by organelle proteins with "typical" monospecific targeting properties.
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Registered trials
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