ArticlePlant signaling & behavior2014
The PHD-finger module of the Arabidopsis thaliana defense regulator EDM2 can recognize triply modified histone H3 peptides.
Article in Plant signaling & behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Transcriptome wide identification, characterization and expression analysis of PHD gene family inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2024Article
- Molecular basis of locus-specific H3K9 methylation catalyzed by SUVH6 in plants.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The Arabidopsis RRM domain protein EDM3 mediates race-specific disease resistance by controlling H3K9me2-dependent alternative polyadenylation of RPP7 immune receptor transcripts.The Plant journal : for cell and molecular biology · 2019Article
- Transcript-level expression control of plant NLR genes.Molecular plant pathology · 2018Review
- Mechanisms to Mitigate the Trade-Off between Growth and Defense.The Plant cell · 2017Review
- Epigenetic Regulation of Intronic Transgenes in Arabidopsis.Scientific reports · 2017Article
- Epigenetic Control of Defense Signaling and Priming in Plants.Frontiers in plant science · 2016Review
- DNA Methylation within Transcribed Regions.Plant physiology · 2015Review
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently we reported that the Arabidopsis thaliana PHD-finger protein EDM2 (enhanced downy mildew 2) impacts disease resistance by affecting levels of di-methylated lysine 9 of histone H3 (H3K9me2) at an alternative polyadenylation site in the immune receptor gene RPP7. EDM2-dependent modulation of this post-translational histone modification (PHM) shifts the balance between full-length RPP7 transcripts and prematurely polyadenylated transcripts, which do not encode the RPP7 protein. Our previous work genetically linked, for the first time, PHMs to alternative polyadenylation and established EDM2 as a critical component mediating PHM-dependent polyadenylation control. However, how EDM2 is recruited to its genomic target sites and how it affects H3K9me2 levels is unknown. Here we show the PHD-finger module of EDM2 to recognize histone H3 bearing certain combinations of 3 distinct PHMs. Our results suggest that targeting of EDM2 to specific genomic regions is mediated by the histone-binding selectivity of its PHD-finger domain.
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