ReviewInternational journal of reproductive medicine2014
The chromosomal constitution of embryos arising from monopronuclear oocytes in programmes of assisted reproduction.
Review in International journal of reproductive medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Could blastocysts derived from abnormal fertilized zygotes be used? A systematic review and meta-analysis.European journal of obstetrics & gynecology and reproductive biology: X · 2025Review
- Birth of Thirty-Two Healthy Babies Following Transfer of Fresh and Frozen-Thawed Embryos Derived from Monopronuclear Zygotes: A Retrospective Study.Medicina (Kaunas, Lithuania) · 2024Article
- Developmental potential of non- and mono-pronuclear zygotes and associated clinical outcomes in IVF cycles.Frontiers in endocrinology · 2024Article
- Developmental competence and neonatal outcomes of nonpronuclear zygotes following single vitrified-warmed blastocyst transfers using propensity score matching analysis.Archives of gynecology and obstetrics · 2024Article
- Assessing the clinical viability of micro 3 pronuclei zygotes.Journal of assisted reproduction and genetics · 2023Article
- The first mitotic division of human embryos is highly error prone.Nature communications · 2022Article
- Haplotype-aware inference of human chromosome abnormalities.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Comparison of the rates for reaching the blastocyst stage between normal and abnormal pronucleus embryos monitored by a time-lapse system in IVF patientsJournal of the Turkish German Gynecological Association · 2021Article
- Genome-wide haplotyping embryos developing from 0PN and 1PN zygotes increases transferrable embryos in PGT-M.Human reproduction (Oxford, England) · 2018Article
- Chromosomal analysis of blastocyst derived from monopronucleated ICSI zygotes: approach by double trophectoderm biopsy.JBRA assisted reproduction · 2017Article
- Could monopronucleated ICSI zygotes be considered for transfer? Analysis through time-lapse monitoring and PGS.Journal of assisted reproduction and genetics · 2017Article
- Evidence of Selection against Complex Mitotic-Origin Aneuploidy during Preimplantation Development.PLoS genetics · 2015Article
- Fertilization, embryo culture, and clinical results using low lactate embryo culture medium for pre-culture, insemination, and beyond.Reproductive medicine and biologyArticle
- Early Fertilization Abnormalities in the Human: An Exhausted Area of Research?Journal of reproduction & infertilityArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The assessment of oocytes showing only one pronucleus during assisted reproduction is associated with uncertainty. A compilation of data on the genetic constitution of different developmental stages shows that affected oocytes are able to develop into haploid, diploid, and mosaic embryos with more or less complex chromosomal compositions. In the majority of cases (~80%), haploidy appears to be caused by gynogenesis, whereas parthenogenesis or androgenesis is less common. Most of the diploid embryos result from a fertilization event involving asynchronous formation of the two pronuclei or pronuclear fusion at a very early stage. Uniparental diploidy may sometimes occur if one pronucleus fails to develop and the other pronucleus already contains a diploid genome or alternatively a haploid genome undergoes endoreduplication. In general, the chance of obtaining a biparental diploid embryo appears higher after conventional in vitro fertilization than after intracytoplasmic sperm injection. If a transfer of embryos obtained from monopronuclear oocytes is envisaged, it should be tried to culture them up to the blastocyst since most haploid embryos are not able to reach this stage. Comprehensive counselling of patients on potential risks is advisable before transfer and a preimplantation genetic diagnosis could be offered if available.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.