ReviewInternational journal of reproductive medicine2013
Metabolite Profiling in the Pursuit of Biomarkers for IVF Outcome: The Case for Metabolomics Studies.
Review in International journal of reproductive medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Metabolomics for improving pregnancy outcomes in women undergoing assisted reproductive technologies.The Cochrane database of systematic reviews · 2018Pooled it
- Metabolomics for improving pregnancy outcomes in women undergoing assisted reproductive technologies.The Cochrane database of systematic reviews · 2017Pooled it
- Investigating the Optimal Time for Intrauterine Human Chorionic Gonadotropin Infusion in Order to Improve IVF Outcome: A Systematic Review and Meta-Analysis.In vivo (Athens, Greece)Pooled it
- Integrated single-cell and metabolomic profiling identifies ovarian metabolic differences and endothelial heterogeneity associated with litter-size variation in Hu sheep.Journal of animal science and biotechnology · 2026Article
- cGAS-STING Signaling as a Molecular Bridge Between Inflammation, Ovarian Ageing, and Reproductive Failure.International journal of molecular sciences · 2026Review
- Follicular Fluid Metabolomics: Tool for Predicting IVF Outcomes of Different Infertility Causes.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Metabolomic profile of dromedary camel follicular fluid during the breeding and non-breeding seasons.Scientific reports · 2025Article
- Serum and follicular fluid metabolome and markers of ovarian stimulation.Human reproduction (Oxford, England) · 2023Article
- The effect of intrauterine hCG injection before embryo transfer on pregnancy rate in frozen embryo transfer cycles.Annals of medicine and surgery (2012) · 2022Article
- Glutamine and norepinephrine in follicular fluid synergistically enhance the antioxidant capacity of human granulosa cells and the outcome of IVF-ET.Scientific reports · 2022Article
- Periconception air pollution, metabolomic biomarkers, and fertility among women undergoing assisted reproduction.Environment international · 2021Article
- Why Has Metabolomics So Far Not Managed to Efficiently Contribute to the Improvement of Assisted Reproduction Outcomes? The Answer through a Review of the Best Available Current Evidence.Diagnostics (Basel, Switzerland) · 2021Article
- Altered Follicular Fluid Metabolic Pattern Correlates with Female Infertility and Outcome Measures of In Vitro Fertilization.International journal of molecular sciences · 2021Article
- Raman Spectrum of Follicular Fluid: A Potential Biomarker for Oocyte Developmental Competence in Polycystic Ovary Syndrome.Frontiers in cell and developmental biology · 2021Article
- Metabolomic Insight into Polycystic Ovary Syndrome-An Overview.International journal of molecular sciences · 2020Review
- Extracellular Vesicles in the Oviduct: Progress, Challenges and Implications for the Reproductive Success.Bioengineering (Basel, Switzerland) · 2019Review
- NMR metabolic profiling of follicular fluid for investigating the different causes of female infertility: a pilot study.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- Hyper response to ovarian stimulation affects the follicular fluid metabolomic profile of women undergoing IVF similarly to polycystic ovary syndrome.Metabolomics : Official journal of the Metabolomic Society · 2018Article
- Gamete activation: basic knowledge and clinical applications.Human reproduction update · 2016Review
- Recent progress in metabolomics for analyzing common infertility conditions that affect ovarian function.Reproductive medicine and biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background. This paper presents the literature on biomarkers of in vitro fertilisation (IVF) outcome, demonstrating the progression of these studies towards metabolite profiling, specifically metabolomics. The need for more, and improved, metabolomics studies in the field of assisted conception is discussed. Methods. Searches were performed on ISI Web of Knowledge SM for literature associated with biomarkers of oocyte and embryo quality, and biomarkers of IVF outcome in embryo culture medium, follicular fluid (FF), and blood plasma in female mammals. Results. Metabolomics in the field of female reproduction is still in its infancy. Metabolomics investigations of embryo culture medium for embryo selection have been the most common, but only within the last five years. Only in 2012 has the first metabolomics investigation of FF for biomarkers of oocyte quality been reported. The only metabolomics studies of human blood plasma in this context have been aimed at identifying women with polycystic ovary syndrome (PCOS). Conclusions. Metabolomics is becoming more established in the field of assisted conception, but the studies performed so far have been preliminary and not all potential applications have yet been explored. With further improved metabolomics studies, the possibility of identifying a method for predicting IVF outcome may become a reality.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.