ReviewGerms2015
Endocrine dysfunction in sepsis: a beneficial or deleterious host response?
Review in Germs, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- The Value of Decreased Thyroid Hormone for Predicting Mortality in Adult Septic Patients: A Systematic Review and Meta-Analysis.Scientific reports · 2018Pooled it
- Frequency and Impact of Thyroid Hormone Abnormalities in COVID-19: An Observational Study at the Peak of the Pandemic.Clinical medicine insights. Endocrinology and diabetes · 2026Article
- Non-Thyroidal Illness Syndrome: A Predictor of Non-Invasive Ventilation Failure and Mortality in Critically Ill Patients.Medicina (Kaunas, Lithuania) · 2025Article
- Endocrine and metabolic alterations in response to systemic inflammation and sepsis: a review article.Molecular medicine (Cambridge, Mass.) · 2025Review
- Association Between Nonthyroidal Illness Syndrome and Disseminated Intravascular Coagulation in Sepsis.Journal of inflammation research · 2024Article
- Serum Cortisol as a Biomarker of Severe Dengue.Tropical medicine and infectious disease · 2023Article
- Different subtypes of nonthyroidal illness syndrome on the prognosis of septic patients: a two-centered retrospective cohort study.Frontiers in endocrinology · 2023Article
- Characterization of Systemic and Regional Hemodynamics and Vascular Dysfunction in Mice with Fecal Induced Peritonitis.Biomedicines · 2022Article
- Refining the Pediatric Multiple Organ Dysfunction Syndrome.Pediatrics · 2022Article
- Sepsis as a Pan-Endocrine Illness-Endocrine Disorders in Septic Patients.Journal of clinical medicine · 2021Review
- Long non-coding RNA pairs to assist in diagnosing sepsis.BMC genomics · 2021Article
- Dynamic Changes in Microbiome Composition Following Mare's Milk Intake for Prevention of Collateral Antibiotic Effect.Frontiers in cellular and infection microbiology · 2021Article
- Theory: Treatments for Prolonged ICU Patients May Provide New Therapeutic Avenues for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).Frontiers in medicine · 2021Article
- Anterior pituitary function in critical illness.Endocrine connections · 2019Review
- Selected Biomarkers Correlate with the Origin and Severity of Sepsis.Mediators of inflammation · 2018Article
- The Central Role of the Inflammatory Response in Understanding the Heterogeneity of Sepsis-3.BioMed research international · 2018Review
- Attempting to define and refine vasopressin use in septic shock: the VANISH trial.Annals of translational medicine · 2016Article
- The interplay between intestinal bacteria and host metabolism in health and disease: lessons from Drosophila melanogaster.Disease models & mechanisms · 2016Review
- Assessment of Diagnostic and Prognostic Role of Copeptin in the Clinical Setting of Sepsis.BioMed research international · 2016Observational
- CENTRAL HYPOTHYROIDISM IN SEVERE SEPSIS.Acta endocrinologica (Bucharest, Romania : 2005)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is a systemic, deleterious inflammatory host response triggered by an infective agent leading to severe sepsis, septic shock and multi-organ failure. The host response to infection involves a complex, organized and coherent interaction between immune, autonomic, neuroendocrine and behavioral systems. Recent data have confirmed that disturbances of the autonomic nervous and neuroendocrine systems could contribute to sepsis-induced organ dysfunction. Through this review, we aimed to summarize the current knowledge about the endocrine dysfunction as response to sepsis, specifically addressed to vasopressin, copeptin, cortisol, insulin and leptin. We searched the following readily accessible, clinically relevant databases: PubMed, UpToDate, BioMed Central. The immune system could be regarded as a "diffuse sensory organ" that signals the presence of pathogens to the brain through different pathways, such as the vagus nerve, endothelial activation/dysfunction, cytokines and neurotoxic mediators and the circumventricular organs, especially the neurohypophysis. The hormonal profile changes substantially as a consequence of inflammatory mediators and microorganism products leading to inappropriately low levels of vasopressin, sick euthyroid syndrome, reduced adrenal responsiveness to ACTH, insulin resistance, hyperglycemia as well as hyperleptinemia. In conclusion, clinical diagnosis of this "pan-endocrine illness" is frequently challenging due to the many limiting factors. The most important benefits of endocrine markers in the management of sepsis may be reflected by their potential to be used as biomarkers in different scoring systems to estimate the severity of the disease and the risk of death.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.