ReviewFrontiers in cellular and infection microbiology2015
Streptococcus mutans-derived extracellular matrix in cariogenic oral biofilms.
Review in Frontiers in cellular and infection microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 180 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
180 citing papers in PubMed, 3 syntheses or guidelines pooled it, 332 citations in OpenAlex.
- Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis.BMC oral health · 2023Pooled it
- Does Curcumin Have an Anticaries Effect? A Systematic Review of In Vitro Studies.Advances in experimental medicine and biology · 2021Pooled it
- Clinical efficacy and the antimicrobial potential of silver formulations in arresting dental caries: a systematic review.BMC oral health · 2020Pooled it
- Biofilm formation following chitosan-based varnish or chlorhexidine-fluoride varnish application in patients undergoing fixed orthodontic treatment: a double blinded randomised controlled trial.BMC oral health · 2021Trial
- Preliminary species-dependent growth responses of selected oral bacteria to e-cigarette Liquids and aerosol extracts: a single-species in vitro study.BMC oral health · 2026Article
- Black Cumin Seed Oil Disrupts Structural Biomass and Attenuates Porphyrin-Associated Maturation in Mature Oral Microcosm Biofilms: An In Vitro Study.Biomedicines · 2026Article
- Modulating Oral Microbiota to Prevent Dental Caries: A Microbial Ecology Approach.Dentistry journal · 2026Review
- Enzymatic tools for the treatment of caries-associated biofilms: Investigating the enzymes of a putative polysaccharide utilization locus from Prevotella melaninogenica and their application against Streptococcus mutans biofilm.World journal of microbiology & biotechnology · 2026Article
- Effects of Acidic Exposure on Surface Properties and Bacterial Adhesion of Three Resin-Based CAD/CAM Materials.Polymers · 2026Article
- Patchouli Alcohol as a Potential Anti-Cariogenic Compound TargetingMolecules (Basel, Switzerland) · 2026Article
- In Vitro Antibacterial and Antibiofilm Effects of Antiseptics and Mouthwashes onPathogens (Basel, Switzerland) · 2026Article
- Microbiome in adult severe caries and cross-kingdom biofilms validation.Clinical oral investigations · 2026Article
- Role of sucrose-dependent exopolysaccharides in the biofilm development ofApplied and environmental microbiology · 2026Article
- Prevotella denticola promotes caries by inducing oral microbial dysbiosis.BMC oral health · 2026Article
- Taguchi optimisation of ZnO and GO-integrated HA nanocomposite with improved antibacterial performance.Scientific reports · 2026Article
- Investigation of the relationship between caries predisposition and salivary characteristics.European oral research · 2026Article
- Artemisinins inhibited the synergistic cariogenic effect betweenFrontiers in cellular and infection microbiology · 2026Article
- Polymethyl methacrylate microplastics affect oral microbiota diversity andFrontiers in microbiology · 2026Article
- Article
- Effect ofAmerican journal of translational research · 2026Article
120 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Biofilms are highly structured microbial communities that are enmeshed in a self-produced extracellular matrix. Within the complex oral microbiome, Streptococcus mutans is a major producer of extracellular polymeric substances including exopolysaccharides (EPS), eDNA, and lipoteichoic acid (LTA). EPS produced by S. mutans-derived exoenzymes promote local accumulation of microbes on the teeth, while forming a spatially heterogeneous and diffusion-limiting matrix that protects embedded bacteria. The EPS-rich matrix provides mechanical stability/cohesiveness and facilitates the creation of highly acidic microenvironments, which are critical for the pathogenesis of dental caries. In parallel, S. mutans also releases eDNA and LTA, which can contribute with matrix development. eDNA enhances EPS (glucan) synthesis locally, increasing the adhesion of S. mutans to saliva-coated apatitic surfaces and the assembly of highly cohesive biofilms. eDNA and other extracellular substances, acting in concert with EPS, may impact the functional properties of the matrix and the virulence of cariogenic biofilms. Enhanced understanding about the assembly principles of the matrix may lead to efficacious approaches to control biofilm-related diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.