ArticleMicrobiome2015
16S gut community of the Cameron County Hispanic Cohort.
Article in Microbiome, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Global Microbiome: Core and Unique Signatures Across Diverse Populations.International journal of molecular sciences · 2026Pooled it
- Meta-analysis of gut microbiome studies identifies disease-specific and shared responses.Nature communications · 2017Pooled it
- Pooled it
- Supplementation of 1-Kestose Modulates the Gut Microbiota Composition to Ameliorate Glucose Metabolism in Obesity-Prone Hosts.Nutrients · 2021Trial
- Dietary Effects, Age, and Urban-Rural Dynamics in Shaping Gut Microbiota of Elderly Vietnamese: A Cross-Sectional Study.Microorganisms · 2025Article
- Detecting and mitigating doppelgänger bias in microbiome data: impacts on machine learning and disease classification.Gut microbes · 2025Article
- Activated carbon ameliorates type 2 diabetes via metabolic remodeling of the gut microbiota.Microbiology spectrum · 2025Article
- Getting to the Heart of the Matter: Exploring the Intersection of Cardiovascular Disease, Sex and Race and How Exercise, and Gut Microbiota Influence these Relationships.Reviews in cardiovascular medicine · 2025Review
- Topology of gut Microbiota Network and Guild-Based Analysis in Chinese Adults.Phenomics (Cham, Switzerland) · 2025Article
- Predicting gut microbiota dynamics in obese individuals from cross-sectional data.Frontiers in cellular and infection microbiology · 2025Article
- Scalable log-ratio lasso regression for enhanced microbial feature selection with FLORAL.Cell reports methods · 2024Article
- Mesenchymal stem cells: a novel therapeutic approach for feline inflammatory bowel disease.Stem cell research & therapy · 2024Article
- Microbial determinants of dementia risk in subjects of Mexican descent with type 2 diabetes living in South Texas.medRxiv : the preprint server for health sciences · 2024Article
- Gut pathobiont enrichment observed in a population predisposed to dementia, type 2 diabetics of Mexican descent living in South Texas.Frontiers in microbiomes · 2024Article
- Enhanced Feature Selection for Microbiome Data using FLORAL: Scalable Log-ratio Lasso Regression.bioRxiv : the preprint server for biology · 2023Article
- Combing fecal microbial community data to identify consistent obesity-specific microbial signatures and shared metabolic pathways.iScience · 2023Article
- Capsaicin modulates Akkermansia muciniphila abundance by enhancing MUCIN2 levels in mice fed with high-fat diets.Food & nutrition research · 2023Article
- Gut Microbiome Alterations Associated with Diabetes in Mexican Americans in South Texas.mSystems · 2022Article
- Microbiome differential abundance methods produce different results across 38 datasets.Nature communications · 2022Article
- The human gut microbiome and health inequities.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundObesity and type 2 diabetes (T2D) are major public health concerns worldwide, and their prevalence has only increased in recent years. Mexican Americans are disproportionately afflicted by obesity and T2D, and rates are even higher in the United States-Mexico border region. To determine the factors associated with the increased risk of T2D, obesity, and other diseases in this population, the Cameron County Hispanic Cohort was established in 2004.
resultsIn this study, we characterized the 16S gut community of a subset of 63 subjects from this unique cohort. We found that these communities, when compared to Human Microbiome Project subjects, exhibit community shifts often observed in obese and T2D individuals in published studies. We also examined microbial network relationships between operational taxonomic units (OTUs) in the Cameron County Hispanic Cohort (CCHC) and three additional datasets. We identified a group of seven genera that form a tightly interconnected network present in all four tested datasets, dominated by butyrate producers, which are often increased in obese individuals while being depleted in T2D patients.
conclusionsThrough a combination of increased disease prevalence and relatively high gut microbial homogeneity in the subset of CCHC members we examined, we believe that the CCHC may represent an ideal community to dissect mechanisms underlying the role of the gut microbiome in human health and disease. The lack of CCHC subject gut community segregation based on all tested metadata suggests that the community structure we observe in the CCHC likely occurs early in life, and endures. This persistent 'disease'-related gut microbial community in CCHC subjects may enhance existing genetic or lifestyle predispositions to the prevalent diseases of the CCHC, leading to increased attack rates of obesity, T2D, non-alcoholic fatty liver disease, and others.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.