ArticleFrontiers in genetics2015
Shared genetic variance between obesity and white matter integrity in Mexican Americans.
Article in Frontiers in genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Neurobehavioral correlates of obesity are largely heritable.Proceedings of the National Academy of Sciences of the United States of America · 2018Trial
- Associations between polygenic risk for obesity, body mass index and cognitive performance: Age as moderating factor.Brain, behavior, & immunity - health · 2026Article
- [White matter microstructural disturbance and its relationship with cognitive function in schizophrenia with comorbidity of metabolic syndrome].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026Article
- Brain deficit patterns of metabolic illnesses overlap with those for major depressive disorder: A new metric of brain metabolic disease.Human brain mapping · 2023Article
- The additive impact of cardio-metabolic disorders and psychiatric illnesses on accelerated brain aging.Human brain mapping · 2022Article
- Higher BMI, but not obesity-related genetic polymorphisms, correlates with lower structural connectivity of the reward network in a population-based study.International journal of obesity (2005) · 2021Article
- Obesity and Race May Explain Differential Burden of White Matter Hyperintensity Load.Clinical interventions in aging · 2021Article
- Evidence for genetic correlation between human cerebral white matter microstructure and inflammation.Human brain mapping · 2019Article
- Shared genetic influences on adolescent body mass index and brain structure: A voxel-based morphometry study in twins.NeuroImage · 2019Article
- Associations between modifiable risk factors and white matter of the aging brain: insights from diffusion tensor imaging studies.Neurobiology of aging · 2019Review
- Genomic kinship construction to enhance genetic analyses in the human connectome project data.Human brain mapping · 2019Article
- White matter microstructure and cognitive decline in metabolic syndrome: a review of diffusion tensor imaging.Metabolism: clinical and experimental · 2018Review
- Disruption of Accumbens and Thalamic White Matter Connectivity Revealed by Diffusion Tensor Tractography in Young Men with Genetic Risk for Obesity.Frontiers in human neuroscience · 2018Article
- Lipid Metabolism, Abdominal Adiposity, and Cerebral Health in the Amish.Obesity (Silver Spring, Md.) · 2017Article
- Contributions of polygenic risk for obesity to PTSD-related metabolic syndrome and cortical thickness.Brain, behavior, and immunity · 2017Article
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Authors and funding
12 authors.
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Abstract
Obesity is a chronic metabolic disorder that may also lead to reduced white matter integrity, potentially due to shared genetic risk factors. Genetic correlation analyses were conducted in a large cohort of Mexican American families in San Antonio (N = 761, 58% females, ages 18-81 years; 41.3 ± 14.5) from the Genetics of Brain Structure and Function Study. Shared genetic variance was calculated between measures of adiposity [(body mass index (BMI; kg/m(2)) and waist circumference (WC; in)] and whole-brain and regional measurements of cerebral white matter integrity (fractional anisotropy). Whole-brain average and regional fractional anisotropy values for 10 major white matter tracts were calculated from high angular resolution diffusion tensor imaging data (DTI; 1.7 × 1.7 × 3 mm; 55 directions). Additive genetic factors explained intersubject variance in BMI (heritability, h (2) = 0.58), WC (h (2) = 0.57), and FA (h (2) = 0.49). FA shared significant portions of genetic variance with BMI in the genu (ρG = -0.25), body (ρG = -0.30), and splenium (ρG = -0.26) of the corpus callosum, internal capsule (ρG = -0.29), and thalamic radiation (ρG = -0.31) (all p's = 0.043). The strongest evidence of shared variance was between BMI/WC and FA in the superior fronto-occipital fasciculus (ρG = -0.39, p = 0.020; ρG = -0.39, p = 0.030), which highlights region-specific variation in neural correlates of obesity. This may suggest that increase in obesity and reduced white matter integrity share common genetic risk factors.
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