Evidence map›Paper›PMID 25762997›Full record

ArticleFrontiers in immunology2015

Macrophages at the fork in the road to health or disease.

Charles D Mills, Laurel L Lenz, Klaus Ley

Registry-linked trialAbstract read
In one paragraph

Article in Frontiers in immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05506371 (Azithromycin as an Adjunct to Scaling and Root Planning Causes an Increase of CD68+, CD163+ Macrophages Density in the Gingival Tissues of Periodontitis Patients), which is not on this map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05506371 nacompletednot on this mapstarted 2017, after this paper: background citation

Azithromycin as an Adjunct to Scaling and Root Planning Causes an Increase of CD68+, CD163+ Macrophages Density in the Gingival Tissues of Periodontitis Patients: a Randomized Controlled Short-term Clinical Trial

TypeinterventionalSponsorUkrainian Medical Stomatological AcademyRan2017 to 2019Enrolled50ConditionsPeriodontitisArmsAz+SRP, SRP, No interventions
3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Heterogeneous macrophages contribute to the pathology of disc herniation induced radiculopathy.The spine journal : official journal of the North American Spine Society · 2022
    Article
  10. Article
  11. Article
  12. Defective efferocytosis of vascular cells in heart disease.Frontiers in cardiovascular medicine · 2022
    Review
  13. Antineuroinflammatory Effect ofOxidative medicine and cellular longevity · 2022
    Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Charles D MillsBioMedical Consultants , Marine on St. Croix, MN , USA.
Laurel L LenzDepartment of Immunology and Microbiology, University of Colorado School of Medicine , Aurora, CO , USA.
Klaus LeyLa Jolla Institute for Allergy and Immunology , La Jolla, CA , USA.

Funding

Immune Modulation by Bacterial AutolysinsR01AI065638 · NIAID · UNIVERSITY OF COLORADO DENVER · PI LENZ, LAUREL L · 2006 to 2016
$3.8M
Myeloid cell interactions with T cells in atherosclerosisR01HL115232 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LEY, KLAUS F. · 2012 to 2018
$3.2M
IFNGR Down Regulation as a Host Target for Therapy of Infectious DiseasesR33AI102264 · NIAID · UNIVERSITY OF COLORADO DENVER · PI LENZ, LAUREL L · 2014 to 2016
$1.1M
NHLBI NIH HHS R01 HL115232NIAID NIH HHS R01 AI065638NIAID NIH HHS R33 AI102264
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

atherosclerosiscancerinfectioninnate immunityM1M2macrophagewound

Identifiers

PMID25762997
PMCPMC4329822

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.