ReviewNestle Nutrition Institute workshop series2012
Influence of inflammatory disorders and infection on iron absorption and efficacy of iron-fortified foods.
Review in Nestle Nutrition Institute workshop series, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Small-quantity lipid-based nutrient supplements for the prevention of child malnutrition and promotion of healthy development: overview of individual participant data meta-analysis and programmatic implications.The American journal of clinical nutrition · 2021Pooled it
- Characteristics that modify the effect of small-quantity lipid-based nutrient supplementation on child anemia and micronutrient status: an individual participant data meta-analysis of randomized controlled trials.The American journal of clinical nutrition · 2021Pooled it
- Nutrition-specific interventions for preventing and controlling anaemia throughout the life cycle: an overview of systematic reviews.The Cochrane database of systematic reviews · 2021Pooled it
- Improved gastrointestinal tolerance and iron status via probiotic use in iron deficiency anaemia patients initiating oral iron replacement: a randomised controlled trial.The British journal of nutrition · 2024Trial
- Iron status, anemia, and birth outcomes among pregnant women in urban Bloemfontein, South Africa: the NuEMI study.BMC pregnancy and childbirth · 2024Article
- Magnitude and associated factors of preoperative anemia among adult elective surgical patients at Saint Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia, 2024.Frontiers in medicine · 2024Article
- Article
- Prevalence and risk factors of anemia in the mother-child population from a region of the Colombian Caribbean.BMC public health · 2023Article
- Implication of asymptomatic and clinical Plasmodium falciparum infections on biomarkers of iron status among school-aged children in Malawi.Malaria journal · 2022Article
- Review
- Anthropometric Markers and Iron Status of 6-12-Year-Old Thai Children: Associations and Predictors.Journal of nutrition and metabolism · 2021Article
- The Role of Reticulocyte Hemoglobin Content for the Diagnosis of Functional Iron Deficiency in Hemodialyzed patients.Saudi journal of biological sciences · 2021Article
- Anemia, iron status, and associated protective and risk factors among children and adolescents aged 3 to 19 years old from four First Nations communities in Quebec.Canadian journal of public health = Revue canadienne de sante publique · 2020Article
- Salivary Cystatin SN Binds to Phytic Acid In Vitro and Is a Predictor of Nonheme Iron Bioavailability with Phytic Acid Supplementation in a Proof of Concept Pilot Study.Current developments in nutrition · 2019Article
- Caesarean delivery and anaemia risk in children in 45 low- and middle-income countries.Maternal & child nutrition · 2018Article
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Funding
Abstract
The provision of iron- fortified foods is a common strategy to prevent iron deficiency; however, ensuring adequate iron absorption is a challenge. Iron bioavailability depends on the choice of iron compound, the presence enhancers and inhibitors of absorption in the food matrix, and the physiological state of the consumer, including iron status, other nutritional deficiencies and inflammatory disorders. Inflammation associated with infections and inflammatory disorders would be expected to decrease iron absorption and reduce the efficacy of iron- fortified foods. The decreased absorption is due to an increase in circulating hepcidin in response to inflammatory cytokines. Hepcidin degrades ferroportin and blocks the passage of iron from the intestinal cell to the plasma. This is the innate immune response to infections and aims to restrict pathogen growth by restricting iron supply. Stable isotope studies have reported women and children with chronic malaria parasitemia or febrile malaria to have increased inflammatory cytokines, increased hepcidin and much decreased iron absorption. No studies have specifically investigated the efficacy of iron- fortified foods in the absence and presence of infections. In contrast, inflammation and increased hepcidin associated with adiposity in overweight have been linked to both lower iron absorption and the decreased efficacy of iron- fortified foods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.