Evidence map›Paper›PMID 25762963›Full record

ArticleFrontiers in psychology2015

The association between mood and anxiety disorders, and coronary heart disease in Brazil: a cross-sectional analysis on the Brazilian longitudinal study of adult health (ELSA-Brasil).

Andrew H Kemp, Andre R Brunoni, Maria A Nunes, Itamar S Santos, Alessandra C Goulart, Antonio L Ribeiro, Isabela M Benseñor, Paulo A Lotufo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 37 citations in OpenAlex.

  1. HRV changes in young adults with depression.Journal of family medicine and primary care · 2024
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  5. Observational
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  8. Mental disorders and heart diseases: from William Harvey to today.Sao Paulo medical journal = Revista paulista de medicina
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Andrew H KempCenter for Clinical and Epidemiologic Research, University Hospital and Faculty of Medicine, University of São Paulo, São Paulo Brazil ; School of Psychology and Discipline of Psychiatry, University of Sydney, Sydney, NSW Australia.
Andre R BrunoniCenter for Clinical and Epidemiologic Research, University Hospital and Faculty of Medicine, University of São Paulo, São Paulo Brazil.
Maria A NunesFaculty of Medicine, Federal University of Rio Grande do Sul, Porto Alegre Brazil.
Itamar S SantosCenter for Clinical and Epidemiologic Research, University Hospital and Faculty of Medicine, University of São Paulo, São Paulo Brazil.
Alessandra C GoulartCenter for Clinical and Epidemiologic Research, University Hospital and Faculty of Medicine, University of São Paulo, São Paulo Brazil.
Antonio L RibeiroHospital das Clínicas and Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte Brazil.
Isabela M BenseñorCenter for Clinical and Epidemiologic Research, University Hospital and Faculty of Medicine, University of São Paulo, São Paulo Brazil.
Paulo A LotufoCenter for Clinical and Epidemiologic Research, University Hospital and Faculty of Medicine, University of São Paulo, São Paulo Brazil.
Universidade de São Paulo · BRHospital das Clínicas da Universidade Federal de Minas Gerais · BRUniversidade Federal do Rio Grande do Sul · BRUniversity of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAssociations between major depressive disorder (MDD) and coronary heart disease (CHD) have been established, and these associations increase risk of future morbidity and mortality. Prior research has been carried out in high-income countries. Here we examine associations between the mood and anxiety disorders, and CHD in a large cohort at baseline from Brazil, a country facing a variety of challenges that may affect these associations.

methodsParticipants included 15,105 civil servants aged 35 to 74 at baseline (2008-2010) from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). CHD (N = 721) included self-reported angina pectoris (n = 305), myocardial infarction (n = 259) and coronary revascularization (n = 239). Hierarchical logistic regression analyses were conducted to estimate odds ratios and confidence intervals.

resultsMajor findings indicate that comorbid MDD and anxiety disorders (n = 434) are associated with a threefold increase in CHD, MDD alone (n = 170) with a twofold increase in CHD, while generalized anxiety disorder alone (n = 1,394) and mixed anxiety and depression disorder (n = 1,844) - symptoms present, but diagnostic threshold not reached - are associated with a 1.5-fold increase in CHD, after full adjustment for covariates.

conclusionThe association with CHD is greatest in those with psychiatric comorbidity, while associations were also observed in MDD and generalized anxiety disorder without comorbidity. While findings are limited by the cross-sectional design of the study, given the known risks associated with comorbidity of the mood and anxiety disorders with CHD, findings reinforce the importance of comprehensive health assessment in Brazil.

Indexed as

anxiety disorderscoronary heart diseasedisorder comorbiditymajor depressive disorder

Identifiers

PMID25762963
PMCPMC4340212
OpenAlexW2032589203

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.