ArticleFrontiers in aging neuroscience2015
Restricted loss of olivocochlear but not vestibular efferent neurons in the senescent gerbil (Meriones unguiculatus).
Article in Frontiers in aging neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Effects of Age on Responses of Principal Cells of the Mouse Anteroventral Cochlear Nucleus in Quiet and Noise.eNeuro · 2024Article
- Single-unit data for sensory neuroscience: Responses from the auditory nerve of young-adult and aging gerbils.Scientific data · 2024Article
- Age-related changes in olivocochlear efferent innervation in gerbils.Frontiers in synaptic neuroscience · 2024Article
- Aged mice are less susceptible to motion sickness and show decreased efferent vestibular activity compared to young adults.Brain and behavior · 2023Article
- Molecular and Functional Changes to Postsynaptic Cholinergic Signaling in the Vestibular Sensory Organs of Aging C57BL/6 Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Altered neural encoding of vowels in noise does not affect behavioral vowel discrimination in gerbils with age-related hearing loss.Frontiers in neuroscience · 2023Article
- Identification of Neural Mechanisms in First Single-Sweep Analysis in oVEMPs and Novel Normative Data.Journal of clinical medicine · 2022Article
- Age-Related Changes in the Cochlea and Vestibule: Shared Patterns and Processes.Frontiers in neuroscience · 2021Review
- Olivocochlear Changes Associated With Aging Predominantly Affect the Medial Olivocochlear System.Frontiers in neuroscience · 2021Article
- Linking anatomical and physiological markers of auditory system degeneration with behavioral hearing assessments in a mouse (Mus musculus) model of age-related hearing loss.Neurobiology of aging · 2020Article
- A review of efferent cholinergic synaptic transmission in the vestibular periphery and its functional implications.Journal of neurophysiology · 2020Review
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- Brain atlas of the Mongolian gerbil (Meriones unguiculatus) in CT/MRI-aided stereotaxic coordinates.Brain structure & function · 2016Article
- Age-Related Neurochemical Changes in the Vestibular Nuclei.Frontiers in neurology · 2016Review
- Editorial: Aging, neurogenesis and neuroinflammation in hearing loss and protection.Frontiers in aging neuroscience · 2015Article
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Authors and funding
3 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Degeneration of hearing and vertigo are symptoms of age-related auditory and vestibular disorders reflecting multifactorial changes in the peripheral and central nervous system whose interplay remains largely unknown. Originating bilaterally in the brain stem, vestibular and auditory efferent cholinergic projections exert feedback control on the peripheral sensory organs, and modulate sensory processing. We studied age-related changes in the auditory and vestibular efferent systems by evaluating number of cholinergic efferent neurons in young adult and aged gerbils, and in cholinergic trigeminal neurons serving as a control for efferents not related to the inner ear. We observed a significant loss of olivocochlear (OC) neurons in aged compared to young adult animals, whereas the overall number of lateral superior olive (LSO) cells was not reduced in aging. Although the loss of lateral and medial olivocochlear (MOC) neurons was uniform and equal on both sides of the brain, there were frequency-related differences within the lateral olivocochlear (LOC) neurons, where the decline was larger in the medial limb of the superior olivary nucleus (high frequency representation) than in the lateral limb (middle-to-low frequency representation). In contrast, neither the number of vestibular efferent neurons, nor the population of motor trigeminal neurons were significantly reduced in the aged animals. These observations suggest differential effects of aging on the respective cholinergic efferent brainstem systems.
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