ArticleMediators of inflammation2015
Reduced serum butyrylcholinesterase activity indicates severe systemic inflammation in critically ill patients.
Article in Mediators of inflammation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Butyrylcholinesterase Activity as a Mortality Marker in ICU Patients: An Individual Participant Data Meta-Analysis.Critical care explorations · 2026Pooled it
- In a secondary analysis from a randomised, double-blind placebo-controlled trial Dexmedetomidine blocks cholinergic dysregulation in delirium pathogenesis in patients with major surgery.Scientific reports · 2023Trial
- Serum cholinesterase as a prognostic marker in respiratory critical illness: a narrative review.Wiener klinische Wochenschrift · 2026Review
- The interaction between the immune system and the autonomic nervous system in the pathophysiology of major depressive disorder: a scoping review.Brain, behavior, & immunity - health · 2026Review
- Monocyte-Containing Inflammatory Indices Show Stronger Association with 30-Day Mortality than the Systemic Immune-Inflammation Index in Elderly Sepsis: A Single-Center Retrospective Observational Cohort Study.Journal of clinical medicine · 2026Article
- The incremental prognostic value of platelet-to-neutrophil and platelet-to-lymphocyte ratios in patients with sepsis: A retrospective cohort study.The Journal of international medical research · 2026Article
- Lower butyrylcholinesterase is associated with postoperative delirium in adult cardiac surgery patients: a secondary analysis of two prospective studies.BMC anesthesiology · 2026Article
- Low serum pseudocholinesterase levels are associated with mortality in patients with hepatocellular carcinoma.Hepatology communications · 2026Article
- Sepsis Drives Severity and Mortality in Acute-on-Chronic Liver Failure Among ICU Patients with Alcohol-Related Cirrhosis: A Retrospective Single-Center Study.Journal of clinical medicine · 2025Article
- Prolonged paralysis following mivacurium administration in a pediatric patient with previously undiagnosed pseudocholinesterase deficiency: a case report.BMC pediatrics · 2025Article
- Serum butyrylcholinesterase activity as a predictor of severity and mortality in COVID-19 patients.Scientific reports · 2025Article
- Novel link between plasma bilirubin and anti-inflammatory miRNA profiles in follicular fluid of IVF patients.American journal of physiology. Endocrinology and metabolism · 2025Article
- Mini meta-analysis of anticholinesterase actions of atorvastatin, simvastatin and rosuvastatin, andToxicology reports · 2025Review
- Butyrylcholinesterase (BChE) downregulation in taxane resistance: implications for prostate cancer.Turkish journal of biology = Turk biyoloji dergisi · 2025Article
- Ameliorating effects ofFood science & nutrition · 2024Article
- Cholinesterase activities and sepsis-associated encephalopathy in viral versus nonviral sepsis.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2024Article
- Optimization of the cardiac delirium index by including age, decrease in butyrylcholinesterase actitivity, preoperative HbA1c, and postoperative hemoglobin levels: results of a secondary analysis of a prospective observational study.Frontiers in cardiovascular medicine · 2024Article
- Butyrylcholinesterase levels correlate with surgical site infection risk and severity after colorectal surgery: a prospective single-center study.Frontiers in surgery · 2024Article
- Serum butyrylcholinesterase as a marker of COVID-19 mortality: Results of the monocentric prospective observational study.Chemico-biological interactions · 2023Observational
- Non-Neuronal Acetylcholinesterase Activity Shows Limited Utility for Early Detection of Sepsis.Biomedicines · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systemic inflammation is an immune response to a nonspecific insult of either infectious or noninfectious origin and remains a challenge in the intensive care units with high mortality rate. Cholinergic neurotransmission plays an important role in the regulation of the immune response during inflammation. We hypothesized that the activity of butyrylcholinesterase (BChE) might serve as a marker to identify and prognose systemic inflammation. By using a point-of-care-testing (POCT) approach we measured BChE activity in patients with severe systemic inflammation and healthy volunteers. We observed a decreased BChE activity in patients with systemic inflammation, as compared to that of healthy individuals. Furthermore, BChE activity showed an inverse correlation with the severity of the disease. Although hepatic function has previously been found essential for BChE production, we show here that the reduced BChE activity associated with systemic inflammation occurs independently of and is thus not caused by any deficit in liver function in these patients. A POCT approach, used to assess butyrylcholinesterase activity, might further improve the therapy of the critically ill patients by minimizing time delays between the clinical assessment and treatment of the inflammatory process. Hence, assessing butyrylcholinesterase activity might help in early detection of inflammation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.