ArticleJournal of clinical microbiology2015
Subtyping novel zoonotic pathogen Cryptosporidium chipmunk genotype I.
Article in Journal of clinical microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 68 citations in OpenAlex.
- Article
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- Deciphering a cryptic minefield: A guide toCurrent research in parasitology & vector-borne diseases · 2025Review
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- Rodent-adaptedOne health (Amsterdam, Netherlands) · 2024Article
- Detection of zoonoticParasite epidemiology and control · 2024Article
- Cryptosporidium species and subtypes identified in human domestic cases through the national microbiological surveillance programme in Sweden from 2018 to 2022.BMC infectious diseases · 2024Article
- Cross-species transmission of Cryptosporidium in wild rodents from the southern region of Zhejiang Province of China and its possible impact on public health.Parasite (Paris, France) · 2024Article
- InvestigatingInternational journal of molecular sciences · 2023Review
- Cryptosporidium mortiferum n. sp. (Apicomplexa: Cryptosporidiidae), the species causing lethal cryptosporidiosis in Eurasian red squirrels (Sciurus vulgaris).Parasites & vectors · 2023Article
- The Occurrence ofPathogens (Basel, Switzerland) · 2023Article
- Novel genotypes ofInternational journal for parasitology. Parasites and wildlife · 2022Article
- An Update on ZoonoticAnimals : an open access journal from MDPI · 2021Review
- Development and Application of aMicroorganisms · 2021Article
- SubtypingPathogens (Basel, Switzerland) · 2021Article
- High Diversity ofPathogens (Basel, Switzerland) · 2021Article
- Molecular Epidemiology of Human Cryptosporidiosis in Low- and Middle-Income Countries.Clinical microbiology reviews · 2021Review
- Development of a Subtyping Tool for Zoonotic PathogenJournal of clinical microbiology · 2021Article
- Subtype Characterization and Zoonotic Potential ofPathogens (Basel, Switzerland) · 2021Article
- Subtype distribution of zoonotic pathogenEmerging microbes & infections · 2020Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cryptosporidium chipmunk genotype I is an emerging zoonotic pathogen in humans. The lack of subtyping tools makes it impossible to determine the role of zoonotic transmission in epidemiology. To identify potential subtyping markers, we sequenced the genome of a human chipmunk genotype I isolate. Altogether, 9,509,783 bp of assembled sequences in 853 contigs were obtained, with an N50 of 117,886 bp and >200-fold coverage. Based on the whole-genome sequence data, two genetic markers encoding the 60-kDa glycoprotein (gp60) and a mucin protein (ortholog of cgd1_470) were selected for the development of a subtyping tool. The tool was used for characterizing chipmunk genotype I in 25 human specimens from four U.S. states and Sweden, one specimen each from an eastern gray squirrel, a chipmunk, and a deer mouse, and 4 water samples from New York. At the gp60 locus, although different subtypes were seen among the animals, water, and humans, the 15 subtypes identified differed mostly in the numbers of trinucleotide repeats (TCA, TCG, or TCT) in the serine repeat region, with only two single nucleotide polymorphisms in the nonrepeat region. Some geographic differences were found in the subtype distribution of chipmunk genotype I from humans. In contrast, only two subtypes were found at the mucin locus, which differed from each other in the numbers of a 30-bp minisatellite repeat. Thus, Cryptosporidium chipmunk genotype I isolates from humans and wildlife are genetically similar, and zoonotic transmission might play a potential role in human infections.
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