ReviewNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2015
Targeting the noradrenergic system for gender-sensitive medication development for tobacco dependence.
Review in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 42 citations in OpenAlex.
- Association of Tobacco Use During Pregnancy, Perceived Stress, and Depression Among Alaska Native Women Participants in the Healthy Pregnancies Project.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Trial
- A preliminary investigation into the effects of doxazosin on cognitive functioning in tobacco-deprived and -satiated smokers.Human psychopharmacology · 2018Trial
- Brain dysfunctions and neurotoxicity induced by psychostimulants in experimental models and humans: an overview of recent findings.Neural regeneration research · 2024Article
- Sex-specific associations of serum cotinine levels with depressive symptoms and sleep disorders in American adults: NHANES 2007-2014.Frontiers in psychiatry · 2024Article
- Therapeutics for Substance-Using Women: The Need to Elucidate Sex-Specific Targets for Better-Tailored Treatments.Handbook of experimental pharmacology · 2023Article
- Gender Differences in Smoking Initiation and Cessation Associated with the Intergenerational Transfer of Smoking across Three Generations: The Nagahama Study.International journal of environmental research and public health · 2022Article
- Investigating sex differences and the effect of drug exposure order in the sensory reward-enhancing effects of nicotine and d-amphetamine alone and in combination.Neuropharmacology · 2022Article
- Stress Allostasis in Substance Use Disorders: Promise, Progress, and Emerging Priorities in Clinical Research.Annual review of clinical psychology · 2020Review
- Variability in nicotine conditioned place preference and stress-induced reinstatement in mice: Effects of sex, initial chamber preference, and guanfacine.Genes, brain, and behavior · 2020Article
- Gender differences in subjective stress and neuroendocrine response to a stress task among individuals with opioid dependence: A pilot study.Addictive behaviors · 2019Article
- Neurobiological and Neurophysiological Mechanisms Underlying Nicotine Seeking and Smoking Relapse.Molecular neuropsychiatry · 2019Review
- Sex differences in stress-related alcohol use.Neurobiology of stress · 2019Review
- Anti-stress neuropharmacological mechanisms and targets for addiction treatment: A translational framework.Neurobiology of stress · 2018Review
- Sex differences in the nicotinic acetylcholine and dopamine receptor systems underlying tobacco smoking addiction.Current opinion in behavioral sciences · 2018Article
- Interaction between noradrenergic and cholinergic signaling in amygdala regulates anxiety- and depression-related behaviors in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Role of Exogenous Progesterone in the Treatment of Men and Women with Substance Use Disorders: A Narrative Review.CNS drugs · 2018Review
- Pharmacotherapy for Co-Occurring Alcohol Use Disorder and Post-Traumatic Stress Disorder: Targeting the Opioidergic, Noradrenergic, Serotonergic, and GABAergic/Glutamatergic Systems.Alcohol research : current reviews · 2018Review
- One-Year Smoking Trajectories Among Established Adult Smokers With Low Baseline Motivation to Quit.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Article
- Atomoxetine in abstinent cocaine users: Sex differences.Data in brief · 2017Article
- Effect of doxazosin on stress reactivity and the ability to resist smoking.Journal of psychopharmacology (Oxford, England) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
introductionTobacco use remains the leading cause of morbidity and mortality for both women and men in the United States, and women often experience poorer smoking cessation outcomes than men. Preliminary evidence suggests there are sex differences in medication effectiveness for smoking cessation. However, current medications do not take into account gender-sensitive treatment development and efficacy, underscoring the importance of this underdeveloped area of research.
methodsWe reviewed preclinical and clinical evidence for gender differences in the inability to quit smoking by examining (a) the effect of increased negative affect and stress reactivity on smoking outcomes in women and (b) smoking for nicotine reinforcement in men. We also reviewed the current literature targeting the noradrenergic system as a novel gender-sensitive treatment strategy for tobacco dependence.
resultsWe hypothesize that noradrenergic agents that normalize noradrenergic activity may differentially attenuate stress reactivity in women and nicotine-related reinforcement in men, indicating that targeting the noradrenergic system for smoking cessation may be effective for both genders, with benefits operating through sex-specific mechanisms.
conclusionsConverging lines of preclinical and clinical evidence suggest that gender-sensitive approaches to medication development for smoking cessation are a critical next step for addressing low quit rates and exacerbated health risks among women. Evidence reviewed indicates that smoking activates different brain systems modulated by noradrenergic activity in women versus men, and noradrenergic compounds may preferentially target these gender-sensitive systems.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.