ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2015
Sex differences in acute relief of abstinence-induced withdrawal and negative affect due to nicotine content in cigarettes.
Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 48 citations in OpenAlex.
- Sex-Specific Mediation of Pre-Quit Smoking Reduction: Secondary Analysis of a Randomized Controlled Trial Extending Varenicline Preloading.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Trial
- Acute Effects of Nicotine on Non-Drug-Related Reward in Smokers and Non-Smokers.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Trial
- Manipulation of Menthol and Nicotine Content in Cigarettes: Effects on Smoking Behavior and Toxicant Exposure in Women Menthol Smokers.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023Trial
- The impacts of actual and perceived nicotine administration on insula functional connectivity with the anterior cingulate cortex and nucleus accumbens.Journal of psychopharmacology (Oxford, England) · 2019Trial
- Effects of reduced nicotine content cigarettes on individual withdrawal symptoms over time and during abstinence.Experimental and clinical psychopharmacology · 2018Trial
- The Effect of Personality Traits and Psychological Resilience of University Students on Psychological Dependence on Cigarettes.Addiction & health · 2026Article
- CHRNA5-A3-B4, CYP2A6, and DBH Genetic Associations With Smoking Cessation Throughout Adulthood Within Two Longitudinal Studies of Women.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Article
- Gender, smoking, and tobacco cessation with pharmacological treatment in a cluster randomized clinical trial.Tobacco induced diseases · 2024Article
- Effect of an intensive tobacco cessation program on the smoker narrative: A content analysis and grounded theory.Tobacco induced diseases · 2024Article
- CHRNA5-A3-B4 and DRD2 Genes and Smoking Cessation Throughout Adulthood: A Longitudinal Study of Women.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023Article
- Variations in the patterns of tobacco usage among indian females - findings from the global adult tobacco survey India.BMC women's health · 2022Article
- Functional connectivity of the anterior insula during withdrawal from cigarette smoking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Smoking-induced craving relief relates to increased DLPFC-striatal coupling in nicotine-dependent women.Drug and alcohol dependence · 2021Article
- Alcohol- and Cigarette-Use Related Behaviors During Quarantine and Physical Distancing Amid COVID-19 in Indonesia.Frontiers in psychiatry · 2021Article
- Potential Moderating Effects of Sex/Gender on the Acute Relative Reinforcing and Subjective Effects of Reduced Nicotine Content Cigarettes in Vulnerable Populations.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Article
- Variability in nicotine conditioned place preference and stress-induced reinstatement in mice: Effects of sex, initial chamber preference, and guanfacine.Genes, brain, and behavior · 2020Article
- Sex differences in the appeal of flavored e-cigarettes among young adult e-cigarette users.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020Article
- Effects of Cigarette Nicotine Content and Menthol Preference on Perceived Health Risks, Subjective Ratings, and Carbon Monoxide Exposure Among Adolescent Smokers.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019Article
- Sex differences in amphetamine-induced dopamine release in the dorsolateral prefrontal cortex of tobacco smokers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Response to reduced nicotine content cigarettes among smokers differing in tobacco dependence severity.Preventive medicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
introductionAcute cigarette smoking may relieve withdrawal and negative affect due to tobacco abstinence to a greater extent in women versus men. Yet, the relative contribution of the cigarette's nicotine content to this sex difference is not clear.
methodsNon-quitting dependent adult smokers (N = 44; 21 males, 23 females) participated in 2 virtually identical sessions, each after abstaining overnight (CO < 10 ppm) and differing only in the nicotine content of the designated cigarette. While blind to brand markings, they consumed a total of 24 puffs in controlled fashion for 2 hr in each session, either from a nicotine (Quest 1, 0.6 mg) or denicotinized (Quest 3, 0.05 mg) cigarette. Withdrawal symptoms were obtained before and after smoking, and negative affect was assessed after each period of cigarette exposure consisting of 6 puffs every 25 min.
resultsMen and women did not differ in baseline withdrawal and negative affect due to overnight abstinence, but reductions in each symptom were significantly influenced by the interaction of sex × nicotine/denicotinized cigarette (both p < .05). In men, but not in women, each symptom was generally decreased more by the nicotine versus denicotinized cigarette, and the nicotine cigarette reduced each to a greater degree in men versus women.
conclusionsSex differences in relief of abstinence-induced withdrawal and negative affect due to the nicotine content in cigarettes are consistent with prior research indicating that nicotine per se, compared to non-nicotine smoke stimuli, is less rewarding in women versus men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.