ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2015
Influence of menstrual cycle phase on neural and craving responses to appetitive smoking cues in naturally cycling females.
Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 55 citations in OpenAlex.
- Feasibility and acceptability of testing a menstrual-cycle timed smoking cessation intervention for women of reproductive age (Project Phase): Results of a pilot randomized control trial.Addictive behaviors · 2022Trial
- Kinetics of oxytocin effects on amygdala and striatal reactivity vary between women and men.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Exogenous progesterone for smoking cessation in men and women: a pilot double-blind, placebo-controlled randomized clinical trial.Addiction (Abingdon, England) · 2019Trial
- Ovarian hormones, hormonal contraceptives and reward processing.BJPsych advances · 2026Article
- Sex and Hormonal Effects on Drug Cue Reactivity and Its Regulation in Human Addiction.Biological psychiatry · 2026Article
- We must look beyond primary reinforcement to understand nicotine use in women.Frontiers in neuroendocrinology · 2026Review
- Nicotine is an Immunosuppressant: Implications for Women's Health and Disease.Journal of neuroimmunology · 2024Review
- Biological sex and hormonal contraceptive associations with drug cue reactivity in cannabis use disorder.Journal of psychiatric research · 2024Article
- Article
- Internet gaming disorder and tobacco use disorder share neural connectivity patterns between the subcortical and the motor network.Human brain mapping · 2023Article
- Review
- The Moderating Role of Sex in the Relation between Cue-Induced Craving and Resting-State Functional Connectivity in the Salience Network of Non-Clinically Diagnosed Drinkers.European addiction research · 2023Article
- Impact of the natural hormonal milieu on ventral striatal responses to appetitive cigarette smoking cues: A prospective longitudinal study.Drug and alcohol dependence reports · 2022Article
- Smoking related attention alteration in chronic obstructive pulmonary disease-smoking comorbidity.BMC pulmonary medicine · 2022Article
- Sex-Dependent Alterations of Regional Homogeneity in Cigarette Smokers.Frontiers in psychiatry · 2022Article
- Smoking-induced craving relief relates to increased DLPFC-striatal coupling in nicotine-dependent women.Drug and alcohol dependence · 2021Article
- Influence of the natural hormonal milieu on brain and behavior in women who smoke cigarettes: Rationale and methodology.Contemporary clinical trials communications · 2021Article
- Baclofen-induced Changes in the Resting Brain Modulate Smoking Cue Reactivity: A Double-blind Placebo-controlled Functional Magnetic Resonance Imaging Study in Cigarette Smokers.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2020Article
- Sex-related differences in subjective, but not neural, cue-elicited craving response in heavy cannabis users.Drug and alcohol dependence · 2020Article
- Caudate reactivity to smoking cues is associated with increased responding to monetary reward in nicotine-dependent individuals.Drug and alcohol dependence · 2020Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
introductionFunctional magnetic resonance imaging (fMRI) has been used extensively in an attempt to understand brain vulnerabilities that mediate maladaptive responses to drug cues. Using perfusion fMRI, we have consistently shown reward-related activation (medial orbitofrontal cortex/ventral striatum) to smoking cues (SCs). Because preclinical and clinical studies generally show that progesterone may reduce reward and craving, we hypothesized that females in the follicular phase of the cycle (FPs; when progesterone levels are low) would have greater reward-related neural responses to SCs compared with females in the luteal phase (LPs).
methodsSated cigarette-dependent premenopausal naturally cycling females underwent pseudo-continuous arterial spin-labeled perfusion fMRI during exposure to 10-min audio visual clips of appetitive SCs and non-SCs. Brain responses to SCs relative to non-SCs were examined among females grouped according to menstrual cycle (MC) phase at the time of scanning (22 FPs, 15 LPs). Craving scores were acquired pre- and post-SC exposure.
resultsFPs showed increased neural responses to SCs compared with non-SCs in the medial orbitofrontal cortex (p ≤ .05 corrected), whereas LPs did not. FPs reported SC-elicited craving (p ≤ .005), whereas LPs did not. Within FPs, SC-induced craving correlated with increased neural responses in the anterior insula (r = 0.73, p < .0001).
conclusionsFPs may be more vulnerable to relapse during appetitive SC exposure than LPs. Because the influence of MC phase on drug cue neural activity has not been examined, these results contribute to our knowledge of the neurobiological underpinnings of responses to drug cues, and they highlight the importance of monitoring menstrual cycle phase in all areas of addiction research.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.