ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2015
Sex differences in hormonal responses to stress and smoking relapse: a prospective examination.
Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- The influence of gender and oxytocin on stress reactivity, cigarette craving, and smoking in a randomized, placebo-controlled laboratory relapse paradigm.Psychopharmacology · 2020Trial
- Nicotine withdrawal alters neural responses to psychosocial stress.Psychopharmacology · 2016Trial
- Exploring hormonal influences on nicotine craving and use across the perinatal period: A prospective longitudinal study.Drug and alcohol dependence reports · 2026Article
- Association between smoking cessation and depressive symptoms according to cessation duration, pack-years, and tobacco product type: a nationwide cross-sectional study in Korea.Frontiers in public health · 2026Article
- Exploring the Relationship Between Brain-Derived Neurotrophic Factor Haplotype Variants, Personality, and Nicotine Usage in Women.International journal of molecular sciences · 2025Article
- Challenges Related to Overcoming Addiction: Assessing Motivation and Readiness to Quit or Reduce Cigarette Smoking.Tobacco use insights · 2025Article
- Neurobiology of Stress-Induced Nicotine Relapse.International journal of molecular sciences · 2024Review
- Gender, smoking, and tobacco cessation with pharmacological treatment in a cluster randomized clinical trial.Tobacco induced diseases · 2024Article
- Genetic Associations with Smoking Relapse and Proportion of Follow-up in Smoking Relapse throughout Adulthood in Pre- and Postmenopausal Women.Cancer prevention research (Philadelphia, Pa.) · 2023Article
- Variations in the patterns of tobacco usage among indian females - findings from the global adult tobacco survey India.BMC women's health · 2022Article
- Circulating ghrelin changes as a biomarker of the stress response and craving in abstinent smokers.Pharmacology, biochemistry, and behavior · 2022Article
- Effects of regular cannabis and nicotine use on acute stress responses: chronic nicotine, but not cannabis use, is associated with blunted adrenocortical and cardiovascular responses to stress.Psychopharmacology · 2022Article
- Cigarette smoke and nicotine effects on behavior in HIV transgenic rats.Behavioural brain research · 2022Article
- Body-Weight Gain in Women During Smoking Cessation Is a Sex-Specific Predictor of 6-Month Abstinence: A Retrospective Cohort Study.Frontiers in public health · 2022Article
- Early life adversity and appetite hormones: The effects of smoking status, nicotine withdrawal, and relapse on ghrelin and peptide YY during smoking cessation.Addictive behaviors · 2021Article
- Article
- Pain Status as a Predictor of Smoking Cessation Initiation, Lapse, and Relapse.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2021Article
- Using novel mobile sensors to assess stress and smoking lapse.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2020Article
- Gender-specific aspects of epidemiology, molecular genetics and outcome: lung cancer.ESMO open · 2020Review
- Brain Marker Links Stress and Nicotine Abstinence.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
introductionDysregulation in the hypothalamic-pituitary-adrenal axis has been shown to be associated with smoking relapse. No study has directly examined the role of sex differences in this relationship.
methodsNicotine dependent men (n = 52) and women (n = 46) interested in cessation completed 2 laboratory stress sessions during ad libitum smoking and after 48 hr of abstinence. The laboratory session included baseline, stress, and recovery periods. Blood and saliva samples were collected at the end of each period for the measurement of cortisol and adrenocorticotropic hormone. Self-report measures of craving and withdrawal symptoms were also collected. Participants attended 4 weekly follow-up sessions for counseling where they provided biological samples and self-report measures including smoking status. Relapse was defined by smoking cigarettes for 7 consecutive days post-cessation.
resultsResults showed that 60 participants relapsed during the 4-week period. Cox regression models from the abstinence session showed that cortisol levels regardless of source were predictive of relapse but the direction of prediction was sex dependent (Sex × Hormone, all ps < .05). Follow-up analyses further revealed that lower cortisol levels predicted relapse in men whereas greater cortisol levels predicted relapse in women (ps < .05). Enhanced craving predicted early smoking relapse in men but not in women (ps < .05). Data from the ad libitum session showed no differences in predicting relapse.
conclusionThese findings highlight that sex differences in the hormonal response to stress and subjective craving during nicotine withdrawal are critical predictors of risk for understanding early relapse.
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