Evidence map›Paper›PMID 25762740›Full record

ArticleJournal of virology2015

Efficient Interaction between Arenavirus Nucleoprotein (NP) and RNA-Dependent RNA Polymerase (L) Is Mediated by the Virus Nucleocapsid (NP-RNA) Template.

Masaharu Iwasaki, Nhi Ngo, Beatrice Cubitt, Juan C de la Torre

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Masaharu IwasakiDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.
Nhi NgoDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.
Beatrice CubittDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.
Juan C de la TorreDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA juanct@scripps.edu.
Scripps Research Institute · US

Funding

REVERSE GENETICS OF ARENAVIRUSESR01AI047140 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI DE LA TORRE, JUAN C. · 2001 to 2011
$3.0M
Anti-interferon Activity of the Arenavirus NucleoproteinR01AI077719 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI DE LA TORRE, JUAN C., MARTINEZ-SOBRIDO, LUIS · 2009 to 2012
$1.6M
NIAID NIH HHS R01 AI047140NIAID NIH HHS R01 AI077719
6 · The paper itself

Abstract

In this study, we document that efficient interaction between arenavirus nucleoprotein (NP) and RNA-dependent RNA polymerase (L protein), the two trans-acting viral factors required for both virus RNA replication and gene transcription, requires the presence of virus-specific RNA sequences located within the untranslated 5' and 3' termini of the viral genome.

Indexed as

ArenavirusGenome, ViralHEK293 CellsHumansLymphocytic choriomeningitis virusNucleocapsidNucleoproteinsRNA-Dependent RNA PolymeraseRNA, UntranslatedRNA, ViralViral ProteinsVirus ReplicationNucleoproteinsRNA-Dependent RNA PolymeraseRNA, UntranslatedRNA, ViralViral Proteins

Identifiers

PMID25762740
PMCPMC4442497
OpenAlexW2148839258

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.