Evidence map›Paper›PMID 25762734›Full record

ArticleJournal of virology2015

Latent herpes simplex virus 1 infection does not induce apoptosis in human trigeminal Ganglia.

Susanne Himmelein, Anja Lindemann, Inga Sinicina, Michael Strupp, Thomas Brandt, Katharina Hüfner

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Susanne HimmeleinDepartment of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany German Center for Vertigo and Balance Disorders, DSGZ, Ludwig Maximilians University, Munich, Germany susanne.himmelein@med.uni-muenchen.de.
Anja LindemannDepartment of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany German Center for Vertigo and Balance Disorders, DSGZ, Ludwig Maximilians University, Munich, Germany.
Inga SinicinaDepartment of Legal Medicine, Ludwig Maximilians University, Munich, Germany.
Michael StruppDepartment of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany German Center for Vertigo and Balance Disorders, DSGZ, Ludwig Maximilians University, Munich, Germany.
Thomas BrandtGerman Center for Vertigo and Balance Disorders, DSGZ, Ludwig Maximilians University, Munich, Germany Institute for Clinical Neurosciences, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany.
Katharina HüfnerDepartment of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany German Center for Vertigo and Balance Disorders, DSGZ, Ludwig Maximilians University, Munich, Germany.
German Center for Lung Research · DELudwig-Maximilians-Universität München · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herpes simplex virus 1 (HSV-1) can establish lifelong latency in human trigeminal ganglia. Latently infected ganglia contain CD8(+) T cells, which secrete granzyme B and are thus capable of inducing neuronal apoptosis. Using immunohistochemistry and single-cell reverse transcription-quantitative PCR (RT-qPCR), higher frequency and transcript levels of caspase-3 were found in HSV-1-negative compared to HSV-1-positive ganglia and neurons, respectively. No terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling (TUNEL) assay-positive neurons were detected. The infiltrating T cells do not induce apoptosis in latently infected neurons.

Indexed as

ApoptosisCaspase 3CD8-Positive T-LymphocytesHerpes SimplexHerpesvirus 1, HumanHost-Pathogen InteractionsHumansMicroRNAsNeuronsTrigeminal GanglionVirus LatencyCASP3 protein, humanCaspase 3latency associated transcript, herpes simplex virus-1MicroRNAs

Identifiers

PMID25762734
PMCPMC4442501
OpenAlexW2036852910

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.