ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Removal of perineuronal nets in the medial prefrontal cortex impairs the acquisition and reconsolidation of a cocaine-induced conditioned place preference memory.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 124 papers.
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Who cites it
124 citing papers in PubMed.
- Blocking human fear memory with the matrix metalloproteinase inhibitor doxycycline.Molecular psychiatry · 2018Trial
- The Role of Meprins on the Brain Extracellular Matrix and Perineuronal Nets.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Disruption of psychostimulant-associated memories by single, low dose ketamine in rats.Neuropharmacology · 2026Article
- Impact of Sema3A Interference on Cerebellum-Dependent Motor Associative Learning and Memory.International journal of molecular sciences · 2026Article
- Adolescent cannabinoid exposure delays development of prefrontal cortex perineuronal nets and inhibitory interneurons.Neuroscience · 2026Article
- Altered molecular signaling pathways in the hippocampus of rhesus monkeys following chronic alcohol use.Scientific reports · 2026Article
- ECM remodeling in the mPFC exacerbates cocaine-induced hyperactivity and impairs threat vigilance.Translational psychiatry · 2026Article
- Ventral pallidal perineuronal nets regulate opioid relapse.bioRxiv : the preprint server for biology · 2026Article
- Prefrontal cortex development and its implications in mental illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Remodeling of Perineuronal Nets in the Striato-Cortical Axis in L-DOPA-Induced Dyskinesia Rat Model.International journal of molecular sciences · 2025Article
- Estrogenic regulation of perineuronal nets in the mouse insular cortex and hippocampus.Neuropharmacology · 2025Article
- Critical Periods and Beyond: Dynamic Functions of Perineuronal Nets in Cognition, Development, and Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Sex-Specific Effects of Experience With Pups on Perineuronal Net Expression in the Biparental California Mouse (Peromyscus californicus).The Journal of comparative neurology · 2025Article
- Differential impacts of germline and adult aggrecan knockout in PV+ neurons on perineuronal nets and PV+ neuronal function.Molecular psychiatry · 2025Article
- Not the same as it ever was: A review of memory modification, updating, and distortion in humans and rodents.Neuroscience and biobehavioral reviews · 2025Review
- Neonatal NLRP3 Inflammasome Activation Leads to Perineuronal Net Deficits in Early Adulthood.Developmental neurobiology · 2025Article
- Enhanced fear extinction through infralimbic perineuronal net digestion: The modulatory role of adolescent alcohol exposure.Alcohol (Fayetteville, N.Y.) · 2025Article
- Combined loss of brevican, neurocan, tenascin-C and tenascin-R leads to impaired fear retrieval due to perineuronal net loss.Scientific reports · 2025Article
- Perineuronal Nets: From Structure to Neurological Disorders.Current medicinal chemistry · 2025Review
- Dorsal raphe to basolateral amygdala corticotropin-releasing factor circuit regulates cocaine-memory reconsolidation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
64 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
Abstract
Pyramidal neurons in the medial prefrontal cortex (mPFC) critically contribute to cocaine-seeking behavior in humans and rodents. Activity of these neurons is significantly modulated by GABAergic, parvalbumin-containing, fast-spiking interneurons, the majority of which are enveloped by specialized structures of extracellular matrix called perineuronal nets (PNNs), which are integral to the maintenance of many types of plasticity. Using a conditioned place preference (CPP) procedure, we found that removal of PNNs primarily from the prelimbic region of the mPFC of adult, male, Sprague Dawley rats impaired the acquisition and reconsolidation of a cocaine-induced CPP memory. This impairment was accompanied by a decrease in the number of c-Fos-positive cells surrounded by PNNs. Following removal of PNNs, the frequency of inhibitory currents in mPFC pyramidal neurons was decreased; but following cocaine-induced CPP, both frequency and amplitude of inhibitory currents were decreased. Our findings suggest that cocaine-induced plasticity is impaired by removal of prelimbic mPFC PNNs and that PNNs may be a therapeutic target for disruption of cocaine CPP memories.
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