ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Differential combinatorial coding of pheromones in two olfactory subsystems of the honey bee brain.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 51 citations in OpenAlex.
- Identification of two odorant receptors tuned to alarm pheromone compounds in the honey bee Apis mellifera.Communications biology · 2025Article
- The fru gene specifies male cooperative behaviors in honeybee colonies.Nature communications · 2025Article
- Evolution of queen pheromone receptor tuning in four honeybee species (Hymenoptera, Apidae, Apis).iScience · 2024Article
- Effects of pesticide-adjuvant combinations used in almond orchards on olfactory responses to social signals in honey bees (Apis mellifera).Scientific reports · 2023Article
- Article
- Gain modulation and odor concentration invariance in early olfactory networks.PLoS computational biology · 2023Article
- Multisite imaging of neural activity using a genetically encoded calcium sensor in the honey bee.PLoS biology · 2023Article
- Antenna movements as a function of odorants' biological value in honeybees (Apis mellifera L.).Scientific reports · 2022Article
- Review
- Review
- Olfactory coding in the antennal lobe of the bumble bee Bombus terrestris.Scientific reports · 2021Article
- Olfactory coding in honeybees.Cell and tissue research · 2021Review
- The neuroethology of olfactory sex communication in the honeybee Apis mellifera L.Cell and tissue research · 2021Review
- Honey Bee Alarm Pheromone Mediates Communication in Plant-Pollinator-Predator Interactions.Insects · 2019Review
- Complementary Specializations of the Left and Right Sides of the Honeybee Brain.Frontiers in psychology · 2019Article
- Neuronal Response Latencies Encode First Odor Identity Information across Subjects.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- In-situ recording of ionic currents in projection neurons and Kenyon cells in the olfactory pathway of the honeybee.PloS one · 2018Article
- Variability in Sexual Pheromones Questions their Role in Bumblebee Pre-Mating Recognition System.Journal of chemical ecology · 2018Article
- Pheromones modulate reward responsiveness and non-associative learning in honey bees.Scientific reports · 2017Article
- Two Parallel Olfactory Pathways for Processing General Odors in a Cockroach.Frontiers in neural circuits · 2017Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural coding of pheromones has been intensively studied in insects with a particular focus on sex pheromones. These studies favored the view that pheromone compounds are processed within specific antennal lobe glomeruli following a specialized labeled-line system. However, pheromones play crucial roles in an insect's life beyond sexual attraction, and some species use many different pheromones making such a labeled-line organization unrealistic. A combinatorial coding scheme, in which each component activates a set of broadly tuned units, appears more adapted in this case. However, this idea has not been tested thoroughly. We focused here on the honey bee Apis mellifera, a social insect that relies on a wide range of pheromones to ensure colony cohesion. Interestingly, the honey bee olfactory system harbors two central parallel pathways, whose functions remain largely unknown. Using optophysiological recordings of projection neurons, we compared the responses of these two pathways to 27 known honey bee pheromonal compounds emitted by the brood, the workers, and the queen. We show that while queen mandibular pheromone is processed by l-ALT (lateral antennal lobe tract) neurons and brood pheromone is mainly processed by m-ALT (median antennal lobe tract) neurons, worker pheromones induce redundant activity in both pathways. Moreover, all tested pheromonal compounds induce combinatorial activity from several AL glomeruli. These findings support the combinatorial coding scheme and suggest that higher-order brain centers reading out these combinatorial activity patterns may eventually classify olfactory signals according to their biological meaning.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.