Evidence map›Paper›PMID 25762641›Full record

ArticleOncotarget2015

P-selectin-mediated platelet adhesion promotes tumor growth.

Cuiling Qi, Bo Wei, Weijie Zhou, Yang Yang, Bin Li, Simei Guo, Jialin Li, Jie Ye, Jiangchao Li, Qianqian Zhang and 6 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.

  1. The Role of P-Selectin in COVID-19 Coagulopathy: An Updated Review.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Cuiling QiVascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China.
Bo WeiDepartment of Gastrointestinal Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, China.
Weijie ZhouDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan 48109, USA.
Yang YangVascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China.
Bin LiVascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China.
Simei GuoVascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China.
Jialin LiVascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China.
Jie YeVascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China.
Jiangchao LiVascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China.
Qianqian ZhangVascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China.
Tian LanVascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China.
Xiaodong HeVascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China.
Liu CaoKey Laboratory of Medical Cell Biology, China Medical University, Shen Yang City, Liao Ning Province 110001, China.
Jia ZhouChemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, USA.
Jianguo GengDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan 48109, USA.
Lijing WangVascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China.
Guangdong Pharmaceutical University · CNUniversity of Michigan–Ann Arbor · USChina Medical University · CNSun Yat-sen University · CNThe University of Texas Medical Branch at Galveston · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Blood platelets foster carcinogenesis. We found that platelets are accumulated in human tumors. P-selectin deficiency and soluble P-selectin abolish platelet deposition within tumors, decreasing secretion of vascular endothelial growth factor and angiogenesis, thereby suppressing tumor growth. Binding of the P-selectin cytoplasmic tail to talin1 triggers the talin1 N-terminal head to interact with the β3 cytoplasmic tail. This activates αIIbβ3 and recruits platelets into tumors. Platelet infiltration into solid tumors occurs through a P-selectin-dependent mechanism.

Indexed as

Cell ProliferationPlatelet AdhesivenessAnimalsBlood PlateletsFemaleHumansInsulinomaMelanoma, ExperimentalMice, Inbred C57BLMice, KnockoutPancreatic NeoplasmsPlatelet Glycoprotein GPIIb-IIIa ComplexProtein BindingP-SelectinSignal TransductionTalinPlatelet Glycoprotein GPIIb-IIIa ComplexP-SelectinSELP protein, humanTalinTln1 protein, mouseplateletsP-selectintalin1tumor growthαIIbβ3

Identifiers

PMID25762641
PMCPMC4466636
OpenAlexW1710493764

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.