Evidence map›Paper›PMID 25762631›Full record

ArticleOncotarget2015

Depletion of eIF2·GTP·Met-tRNAi translation initiation complex up-regulates BRCA1 expression in vitro and in vivo.

Bertal H Aktas, Paula Bordelois, Selen Peker, Sophia Merajver, Jose A Halperin

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Bertal H AktasDivision of Hematology, Brigham and Women's Hospital, Boston, MA, USA.
Paula BordeloisHarvard Medical School, Boston, MA, USA.
Selen PekerDivision of Hematology, Brigham and Women's Hospital, Boston, MA, USA.
Sophia MerajverDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Jose A HalperinDivision of Hematology, Brigham and Women's Hospital, Boston, MA, USA.
Harvard University · USAnkara University · TRUniversity of Michigan–Ann Arbor · US

Funding

NEW TRANSLATION INITIATION INHIBITORS FOR CANCER THERAPYU19CA087427 · NCI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI HALPERIN, JOSE A · 2000 to 2004
$5.1M
Prostate Cancer Prevention by n-3 Unsaturated Fatty AcidsR01CA101034 · NCI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI HALPERIN, JOSE A · 2005 to 2008
$2.1M
Targeting Endoplasmic Reticulum Stress Response for Cancer TherapyR01CA152312 · NCI · HARVARD MEDICAL SCHOOL · PI AKTAS, BERTAL H. · 2011 to 2015
$1.8M
INHIBITION OF TRANSLATION INITIATION IN CANCER THERAPYR01CA078411 · NCI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI HALPERIN, JOSE A · 1998 to 2005
$1.5M
NCI NIH HHS 1R01CA152312NCI NIH HHS CA101034NCI NIH HHS CA78411NCI NIH HHS R01 CA078411NCI NIH HHS R01 CA101034NCI NIH HHS R01 CA152312NCI NIH HHS U19 CA087427NCI NIH HHS U19 CA87427
6 · The paper itself

Abstract

Most sporadic breast and ovarian cancers express low levels of the breast cancer susceptibility gene, BRCA1. The BRCA1 gene produces two transcripts, mRNAa and mRNAb. mRNAb, present in breast cancer but not in normal mammary epithelial cells, contains three upstream open reading frames (uORFs) in its 5'UTR and is translationally repressed. Comparable tandem uORFs are characteristically seen in mRNAs whose translational efficiency paradoxically increases when the overall translation rate is decreased due to phosphorylation of eukaryotic translation initiation factor 2 α (eIF2α). Here we show fish oil derived eicosopanthenoic acid (EPA) that induces eIF2α phosphorylation translationally up-regulates the expression of BRCA1 in human breast cancer cells. We demonstrate further that a diet rich in EPA strongly induces expression of BRCA1 in human breast cancer xenografts.

Indexed as

5' Untranslated RegionsAnimalsBRCA1 ProteinBreast NeoplasmsCell Line, TumorEicosapentaenoic AcidEukaryotic Initiation Factor-2FemaleFish OilsGuanosine TriphosphateHumansMCF-7 CellsMiceMice, NudeNeoplasm TransplantationOpen Reading Frames5' Untranslated RegionsBRCA1 ProteinBRCA1 protein, humanEicosapentaenoic AcidEukaryotic Initiation Factor-2Fish OilsGuanosine TriphosphateRNA, MessengerRNA, Transfer, MetBRCA1eIF2·GTP·Met-tRNAiEPAfish oiluORF

Identifiers

PMID25762631
PMCPMC4466658
OpenAlexW1862585754

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.