ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2015
Genetics of Bone Mass in Childhood and Adolescence: Effects of Sex and Maturation Interactions.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 50 citations in OpenAlex.
- Genetic Risk Scores Implicated in Adult Bone Fragility Associate With Pediatric Bone Density.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016Trial
- Development of the Muscular and Skeletal System During Adolescence.Advances in experimental medicine and biology · 2026Review
- The gSOS polygenic score is associated with bone density and fracture risk in childhood.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- Race-neutral Pediatric Reference Ranges for Bone Mineral Density Predict Prospective Fractures in Childhood.The Journal of clinical endocrinology and metabolism · 2025Article
- Bridging Genomic Research Disparities in Osteoporosis GWAS: Insights for Diverse Populations.Current osteoporosis reports · 2025Review
- Sex differences in physical activity dose-response effects on site-specific bone mineral density during childhood and adolescence.Scientific reports · 2025Article
- The Role of Nutraceuticals and Probiotics in Addition to Lifestyle Intervention in the Management of Childhood Obesity-Part 2: Comorbidities.Nutrients · 2025Review
- Bone Health and Physical Activity - The Complex Mechanism.Aging and disease · 2024Review
- Relationship between Body Mass Index and Bone Turnover Markers in Girls with Idiopathic Central Precocious Puberty.International journal of clinical practice · 2023Article
- wnt16 regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyotome.PLoS genetics · 2022Article
- Influence of dietary patterns and physical activity on bone mineral content and density, osteoporosis among children with stimulant use.Frontiers in pediatrics · 2022Article
- TMEM263: a novel candidate gene implicated in human autosomal recessive severe lethal skeletal dysplasia.Human genomics · 2021Article
- Factors influencing peak bone mass gain.Frontiers of medicine · 2021Review
- Genome-wide association study implicates novel loci and reveals candidate effector genes for longitudinal pediatric bone accrual.Genome biology · 2021Article
- Dual-energy X-ray absorptiometry bone densitometry in pediatrics: a practical review and update.Pediatric radiology · 2021Review
- Evolutionary Perspectives on the Developing Skeleton and Implications for Lifelong Health.Frontiers in endocrinology · 2020Review
- The Bones of Children With Obesity.Frontiers in endocrinology · 2020Review
- Using zebrafish to study skeletal genomics.Bone · 2019Review
- Postmenopausal osteoporotic fracture-associated COLIA1 variant impacts bone accretion in girls.Bone · 2019Article
- Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density.Nature communications · 2019Article
Corrections and comments
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Authors and funding
12 authors at 8 institutions in 2 countries.
Funding
Abstract
We aimed to determine if adult bone mineral density (BMD) susceptibility loci were associated with pediatric bone mass and density, and if sex and pubertal stage influenced any association. We analyzed prospective areal BMD (aBMD) and bone mineral content (BMC) data from the Bone Mineral Density in Childhood Study (n = 603, European ancestry, 54% female). Linear mixed models were used to assess if 77 single-nucleotide polymorphisms (SNPs) near known adult BMD susceptibility loci interacted with sex and pubertal stage to influence the aBMD/BMC; adjusting for age, BMI, physical activity, and dietary calcium. The strongest main association was observed between an SNP near C7orf58 and distal radius aBMD. However, this association had a significant sex • SNP interaction, revealing a significant association only in females (b = -0.32, p = 1.8 × 10(-6)). Furthermore, the C12orf23 locus had significant interactions with both sex and pubertal stage, revealing associations in females during Tanner stage I for total hip aBMD (b = 0.24, p = 0.001) and femoral neck aBMD (b = 0.27, p = 3.0 × 10(-5)). In contrast, the sex • SNP interactions for loci near LRP5 and WNT16 uncovered associations that were only in males for total body less head BMC (b = 0.22, p = 4.4 × 10(-4)) and distal radius aBMD (b = 0.27, p = 0.001), respectively. Furthermore, the LRP5 locus interacted with both sex and pubertal stage, demonstrating associations that were exclusively in males during Tanner V for total hip aBMD (b = 0.29, p = 0.003). In total, significant sex • SNP interactions were found at 15 loci; pubertal stage • SNP interactions at 23 loci and 19 loci interacted with both sex and pubertal stage. In conclusion, variants originally associated with adult BMD influence bone mass in children of European ancestry, highlighting the fact that many of these loci operate early in life. However, the direction and magnitude of associations for a large number of SNPs only became evident when accounting for sex and maturation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.