ArticleJournal of cancer research and clinical oncology2015
p53 target gene Rap2B regulates the cytoskeleton and inhibits cell spreading.
Article in Journal of cancer research and clinical oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Transcriptomic differences in chromatin and cell cycle regulation in A549 cells after irradiation with carbon ions and X-rays.Frontiers in oncology · 2026Article
- Molecular Associations and Clinical Significance of RAPs in Hepatocellular Carcinoma.Frontiers in molecular biosciences · 2021Article
- p53 deficiency triggers dysregulation of diverse cellular processes in physiological oxygen.The Journal of cell biology · 2020Article
- The Impact of p53 on Aristolochic Acid I-Induced Gene Expression In Vivo.International journal of molecular sciences · 2019Article
- Inferring novel genes related to colorectal cancer via random walk with restart algorithm.Gene therapy · 2019Article
- Article
- Knockdown of Rap2B Inhibits the Proliferation and Invasion in Hepatocellular Carcinoma Cells.Oncology research · 2017Article
- Rap2B promotes cell proliferation, migration and invasion in prostate cancer.Medical oncology (Northwood, London, England) · 2016Article
- Rap2B GTPase: structure, functions, and regulation.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeCell migration requires spatiotemporal integration of signals that target cytoskeletal. Previous studies have indicated that Rho GTPases are crucial regulators of actin dynamics. As homologs of Rho proteins, the role of Rap2B in the regulation of cytoskeleton and its cell signaling pathway remains unknown.
methodsThe cellular functions of Rap2B were monitored by Western blotting and immunofluorescence staining in order to characterize the protein level and the cell shape.
resultsHere, we show that expression of Rap2B was induced by nocodazole in a p53-dependent manner. However, Rap2B itself is not necessary for p53-dependent cell cycle arrest. We evidenced that over-expression of Rap2B may inhibit cell spreading by disrupting actin dynamics upon nocodazole treatment, but Rap2B (C180A) mutant does not. In contrast, knockdown of Rap2B promoted cell spreading.
conclusionsAltogether, these results revealed that Rap2B plays a pivotal role in cytoskeleton reorganization and subsequently inhibits cell spreading, which could be responsible for cancer metastasis.
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Registered trials
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