Evidence map›Paper›PMID 25762013›Full record

ArticleEuropean journal of nutrition2016

Antioxidant vitamin intake and mortality in three Central and Eastern European urban populations: the HAPIEE study.

Urszula Stepaniak, Agnieszka Micek, Giuseppe Grosso, Denes Stefler, Roman Topor-Madry, Ruzena Kubinova, Sofia Malyutina, Anne Peasey, Hynek Pikhart, Yuri Nikitin and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 6 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 6 syntheses or guidelines pooled it, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 5 countries.

Urszula StepaniakDepartment of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Grzegorzecka Street 20, Krakow, 31-531, Poland. mxbiela@cyf-kr.edu.pl.
Agnieszka MicekDepartment of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Grzegorzecka Street 20, Krakow, 31-531, Poland.
Giuseppe GrossoDepartment of Clinical and Molecular Biomedicine, Section of Pharmacology and Biochemistry, University of Catania, Catania, Italy.
Denes SteflerDepartment of Epidemiology and Public Health, University College London, London, UK.
Roman Topor-MadryDepartment of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Grzegorzecka Street 20, Krakow, 31-531, Poland.
Ruzena KubinovaNational Institute of Public Health, Prague, Czech Republic.
Sofia MalyutinaInstitute of Internal and Preventive Medicine Siberian Branch Under the Russian Academy of Medical Sciences, Novosibirsk, Russia.
Anne PeaseyDepartment of Epidemiology and Public Health, University College London, London, UK.
Hynek PikhartDepartment of Epidemiology and Public Health, University College London, London, UK.
Yuri NikitinInstitute of Internal and Preventive Medicine Siberian Branch Under the Russian Academy of Medical Sciences, Novosibirsk, Russia.
Martin BobakDepartment of Epidemiology and Public Health, University College London, London, UK.
Andrzej PająkDepartment of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Grzegorzecka Street 20, Krakow, 31-531, Poland.
Jagiellonian University · PLUniversity College London · GBNational Institute of Public Health · CZNovosibirsk State Medical University · RUResearch Institute of Therapy and Preventive Medicine · RUUniversity of Catania · IT

Funding

Health disparities and agingin societies in transitionR01AG023522 · NIA · UNIVERSITY COLLEGE LONDON · PI MARMOT, MICHAEL G · 2004 to 2008
$2.2M
NIA NIH HHS 1R01 AG23522-01NIA NIH HHS R01 AG023522Wellcome TrustWellcome Trust 064947/Z/01/ZWellcome Trust 081081/Z/06/Z
6 · The paper itself

Abstract

purposeThe aim of the study was to assess the relationships between individual-level dietary intakes of antioxidant vitamins C, E and beta-carotene with all-cause and cause-specific mortality in three Central and Eastern European (CEE) populations.

methodsData from the Health, Alcohol and Psychosocial factors in Eastern Europe cohort study were used. At the baseline survey, between 2002 and 2005, 28,945 men and women aged 45-69 years were examined in Novosibirsk (Russia), Krakow (Poland) and seven Czech towns. Deaths in the cohorts were identified through mortality registers. Cox regression was used to estimate the association between vitamin consumption and all-cause, cardiovascular (CVD) disease and cancer mortality.

resultsIn multivariable-adjusted analyses, there were no clear inverse associations between antioxidant vitamin intakes and mortality, although in some groups, several hazard ratios (HRs) were significant. For example, in men, compared with the lowest quintile of vitamin C intake, all-cause mortality in the third and fourth quintiles was lower by 28 % (HR 0.72; 95 % CI 0.61-0.85) and by 20 % (HR 0.80; 95 % CI 0.68-0.95), respectively. CVD mortality was lower by 35 % (HR 0.65; 95 % CI 0.50-0.84) and by 23 % (HR 0.77; 95 % CI 0.59-0.99) in third and fourth quintile of vitamin C intake, respectively. In women, the third and fourth quintiles of dietary intake of vitamin E were associated with reduced risk of all-cause death by 33 % (HR 0.67; 95 % CI 0.53-0.84) and by 23 % (HR 0.77; 95 % CI 0.61-0.97), respectively. Consumption of vitamin C, vitamin E and beta-carotene was not related to CVD mortality in women and to cancer mortality in either gender.

conclusionThis large prospective cohort study in CEE populations with low prevalence of vitamin supplementation did not find a strong, dose-response evidence for protective effects of antioxidant vitamin intake.

Indexed as

Urban PopulationAgedAntioxidantsAscorbic Acidbeta CaroteneCardiovascular DiseasesCause of DeathCzech RepublicDietary SupplementsFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasmsPolandAntioxidantsAscorbic Acidbeta CaroteneVitamin EVitaminsAntioxidant vitaminCardiovascularCentral and Eastern EuropeMortality

Identifiers

PMID25762013
PMCPMC4767874
OpenAlexW2029939023

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.