ArticlePsychopharmacology2015
Differential involvement of anxiety and novelty preference levels on oral ethanol consumption in rats.
Article in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Influence of sex, anxiety, and risk-taking behavior on opioid and alcohol polysubstance consumption patterns.Addiction neuroscience · 2026Article
- Behavioral profile predicts ethanol preference in adolescent mice, but not in adults: A machine learning approach.Alcohol, clinical & experimental research · 2026Article
- Anxiety and risk-taking behavior maps onto opioid and alcohol polysubstance consumption patterns in male and female mice.bioRxiv : the preprint server for biology · 2025Article
- Article
- Brain-specific serine/threonine-protein kinase 1 is a substrate of protein kinase C epsilon involved in sex-specific ethanol and anxiety phenotypes.Addiction biology · 2024Article
- Cocaine and amphetamine regulated transcript (CART) mediates sex differences in binge drinking through central taste circuits.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Article
- Adolescent Ethanol Exposure: Anxiety-Like Behavioral Alterations, Ethanol Intake, and Sensitivity.Frontiers in behavioral neuroscience · 2020Article
- Alcohol-induced conditioned place preference negatively correlates with anxiety-like behavior in adolescent mice: inhibition by a neurokinin-1 receptor antagonist.Psychopharmacology · 2018Article
- Voluntary ethanol consumption changes anticipatory ultrasonic vocalizations but not novelty response.Behavioural brain research · 2017Article
- Orexin/hypocretin-1 receptor antagonism reduces ethanol self-administration and reinstatement selectively in highly-motivated rats.Brain research · 2017Article
- Novelty Seeking and Drug Addiction in Humans and Animals: From Behavior to Molecules.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2016Review
- Role of ethanol-derived acetaldehyde in operant oral self-administration of ethanol in rats.Psychopharmacology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleDrug addiction is defined as a recurring cycle of intoxication, abstinence and relapse. The behavioural trait of novelty seeking is frequently observed in alcohol abusers. Moreover, converging evidence indicates that anxious individuals are also predisposed to alcohol abuse.
objectivesWe have analyzed the respective implication of those two behavioural factors on vulnerability to ethanol intake on rats in situations designed to reflect drug intoxication and relapse phases in humans.
methodsIn a general population of Wistar rats, animals were tested in both the light/dark box and the novelty preference tests. Ethanol consumption was measured in a two-bottle free-choice procedure across three successive procedures. Animals were first exposed to increasing concentrations of ethanol (2, 4, 6, 8, 10, 12 % for 8 days at each concentration). Then, the concentration of the solution was diminished from 12 to 6 %. Finally, all rats were re-exposed to 6 % ethanol after 12 days of ethanol deprivation.
resultsNovelty preference predicted the amount of ethanol consumed across all phases. In contrast, anxiety was associated with a quicker recovery of ethanol consumption after the concentration drop and a greater increase in ethanol consumption after deprivation.
conclusionsNovelty seeking and anxiety are both but differentially implicated in predisposition to ethanol abuse. Whereas novelty seeking is related to the amount of ethanol consumed, anxiety is associated to higher ethanol consumption when ethanol concentration is decreased or after ethanol deprivation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.