ArticleScientific reports2015
Amphiphilic p-sulfonatocalix[4]arene as "drug chaperone" for escorting anticancer drugs.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Research progress on calixarene/pillararene-based controlled drug release systems.Beilstein journal of organic chemistry · 2025Review
- Article
- Co-Loading of Temozolomide and Curcumin into a Calix[4]arene-Based Nanocontainer for Potential Combined Chemotherapy: Binding Features, Enhanced Drug Solubility and Stability in Aqueous Medium.Nanomaterials (Basel, Switzerland) · 2021Article
- Article
- Fluorescent Supramolecular Assembly with Coronene Centers for Controlled DNA Condensation and Drug Delivery.ACS omega · 2019Article
- Chemotherapy Based on Supramolecular Chemistry: A Promising Strategy in Cancer Therapy.Pharmaceutics · 2019Review
- Host-Guest Chemistry in Supramolecular Theranostics.Theranostics · 2019Review
- Orthogonal self-assembly of an organoplatinum(II) metallacycle and cucurbit[8]uril that delivers curcumin to cancer cells.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Pillar[5]arene-based amphiphilic supramolecular brush copolymer: fabrication, controllable self-assembly and application in self-imaging targeted drug delivery.Polymer chemistry · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Supramolecularly constructing multifunctional platform for drug delivery is a challenging task. In this work, we propose a novel supramolecular strategy "drug chaperone", in which macrocyclic amphiphiles directly coassemble with cationic drugs into a multifunctional platform and its surface is further decorated with targeting ligands through host-guest recognition. The coassembling and hierarchical decoration processes were monitored by optical transmittance measurements, and the size and morphology of amphiphilic coassemblies were identified by dynamic light scattering and high-resolution transmission electron microscopy. In cell experiments to validate the drug chaperone strategy, the anticancer activities of free drugs were pronouncedly improved by coassembling with amphiphilic chaperone and further functionalization with targeting ligand.
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