Evidence map›Paper›PMID 25761736›Full record

SynthesisWorld journal of urology2015

Multiparametric ultrasound in the detection of prostate cancer: a systematic review.

Arnoud Postema, Massimo Mischi, Jean de la Rosette, Hessel Wijkstra

Registry-linked trialAbstract readSystematic Review
In one paragraph

Synthesis in World journal of urology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03101176 (Multiparametric Ultrasound), which is not on this map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03101176 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Multiparametric Ultrasound (mpUS) as Imaging Modality for the Detection and Localization of Prostate Cancer

TypeinterventionalSponsorAcademisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)Ran2017 to 2022Enrolled200ConditionsProstate Cancer, Prostatic NeoplasmsArmsSonoVue
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Microultrasound imaging for accuracy of diagnosis in prostate cancer: a single‑center observational study.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2025
    Article
  6. Article
  7. Article
  8. Evaluation of 3D ARFI imaging of prostate cancer: diagnostic reliability and concordance with MpMRI.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Arnoud PostemaDepartment of Urology, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. a.w.postema@amc.uva.nl.
Massimo MischiDepartment of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Jean de la RosetteDepartment of Urology, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Hessel WijkstraDepartment of Urology, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the advances and clinical results of the different ultrasound modalities and the progress in combining them into multiparametric UltraSound (mpUS).

methodsA systematic literature search on mpUS and the different ultrasound modalities included: greyscale ultrasound, computerized transrectal ultrasound, Doppler and power Doppler techniques, dynamic contrast-enhanced ultrasound and (shear wave) elastography.

resultsLimited research available on combining ultrasound modalities has presented improvement in diagnostic performance. The data of two studies suggest that even adding a lower performing ultrasound modality to a better performing modality using crude methods can already improve the sensitivity by 13-51 %. The different modalities detect different tumours. No study has tried to combine ultrasound modalities employing a system similar to the PIRADS system used for mpMRI or more advanced classifying algorithms.

conclusionAvailable evidence confirms that combining different ultrasound modalities significantly improves diagnostic performance.

Indexed as

Contrast MediaElasticity Imaging TechniquesHumansMaleProstatic NeoplasmsReproducibility of ResultsUltrasonography, DopplerContrast MediaANNA/C-TRUSContrast-enhanced ultrasoundDopplerElastographyMultiparametric MRIMultiparametric UltraSoundProstate cancerShear wave elastography

Identifiers

PMID25761736
PMCPMC4617844

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.