ArticleProceedings. Biological sciences2015
Expression of parasite genetic variation changes over the course of infection: implications of within-host dynamics for the evolution of virulence.
Article in Proceedings. Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Article
- Disentangling the role of parasite infectivity and density from host susceptibility in infection development and parasite proliferation.Biology letters · 2025Article
- Pharmaceutical pollution alters the cost of bacterial infection and its relationship to pathogen load.Proceedings. Biological sciences · 2024Article
- Is there a sicker sex? Dose relationships modify male-female differences in infection prevalence.Proceedings. Biological sciences · 2024Article
- Can pharmaceutical pollution alter the spread of infectious disease? A case study using fluoxetine.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Infection burdens and virulence under heat stress: ecological and evolutionary considerations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Out of the 'host' box: extreme off-host conditions alter the infectivity and virulence of a parasitic bacterium.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Decomposing virulence to understand bacterial clearance in persistent infections.Nature communications · 2022Article
- Genotypic variation in an ecologically important parasite is associated with host species, lake and spore size.Parasitology · 2021Article
- Temperature and pathogen exposure act independently to drive host phenotypic trajectories.Biology letters · 2021Article
- Pathogen exposure reduces sexual dimorphism in a host's upper thermal limits.Ecology and evolution · 2020Article
- Sequential co-infections drive parasite competition and the outcome of infection.The Journal of animal ecology · 2020Article
- An alternative route of bacterial infection associated with a novel resistance locus in the Daphnia-Pasteuria host-parasite system.Heredity · 2020Article
- Disentangling non-specific and specific transgenerational immune priming components in host-parasite interactions.Proceedings. Biological sciences · 2020Article
- Infection in patchy populations: Contrasting pathogen invasion success and dispersal at varying times since host colonization.Evolution letters · 2019Article
- Can pathogens optimize both transmission and dispersal by exploiting sexual dimorphism in their hosts?Biology letters · 2019Article
- Assessment of parasite virulence in a natural population of a planktonic crustacean.BMC ecology · 2019Article
- Linking sex differences to the evolution of infectious disease life-histories.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- The impact of host sex on the outcome of co-infection.Scientific reports · 2017Article
- The trans-generational impact of population density signals on host-parasite interactions.BMC evolutionary biology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How infectious disease agents interact with their host changes during the course of infection and can alter the expression of disease-related traits. Yet by measuring parasite life-history traits at one or few moments during infection, studies have overlooked the impact of variable parasite growth trajectories on disease evolution. Here we show that infection-age-specific estimates of host and parasite fitness components can reveal new insight into the evolution of parasites. We do so by characterizing the within-host dynamics over an entire infection period for five genotypes of the castrating bacterial parasite Pasteuria ramosa infecting the crustacean Daphnia magna. Our results reveal that genetic variation for parasite-induced gigantism, host castration and parasite spore loads increases with the age of infection. Driving these patterns appears to be variation in how well the parasite maintains control of host reproduction late in the infection process. We discuss the evolutionary consequences of this finding with regard to natural selection acting on different ages of infection and the mechanism underlying the maintenance of castration efficiency. Our results highlight how elucidating within-host dynamics can shed light on the selective forces that shape infection strategies and the evolution of virulence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.