ArticleCerebral cortex (New York, N.Y. : 1991)2015
Synaptic Conductance Estimates of the Connection Between Local Inhibitor Interneurons and Pyramidal Neurons in Layer 2/3 of a Cortical Column.
Article in Cerebral cortex (New York, N.Y. : 1991), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 27 citations in OpenAlex.
- Excitatory/inhibitory ratio disruption modulates neural synchrony and flow directions in a cortical microcircuit.PLoS computational biology · 2025Article
- A comprehensive data-driven model of cat primary visual cortex.PLoS computational biology · 2024Article
- The role of superficial and deep layers in the generation of high frequency oscillations and interictal epileptiform discharges in the human cortex.Scientific reports · 2023Article
- Unitary synaptic responses of parvalbumin interneurons evoked by excitatory neurons in the mouse barrel cortex.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- A microcircuit model involving parvalbumin, somatostatin, and vasoactive intestinal polypeptide inhibitory interneurons for the modulation of neuronal oscillation during visual processing.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Recovery kinetics of short-term depression of GABAergic and glutamatergic synapses at layer 2/3 pyramidal cells in the mouse barrel cortex.Frontiers in cellular neuroscience · 2023Article
- Disinhibitory circuit mediated by connections from vasoactive intestinal polypeptide to somatostatin interneurons underlies the paradoxical decrease in spike synchrony with increased border ownership selective neuron firing rate.Frontiers in computational neuroscience · 2022Article
- Unique properties of dually innervated dendritic spines in pyramidal neurons of the somatosensory cortex uncovered by 3D correlative light and electron microscopy.PLoS biology · 2021Article
- Persistent sodium current blockers can suppress seizures caused by loss of low-threshold D-type potassium currents: Predictions from an in silico study of KEpilepsia open · 2020Article
- Reconstructing neuronal circuitry from parallel spike trains.Nature communications · 2019Article
- Leveraging heterogeneity for neural computation with fading memory in layer 2/3 cortical microcircuits.PLoS computational biology · 2019Article
- Quantifying How Staining Methods Bias Measurements of Neuron Morphologies.Frontiers in neuroinformatics · 2019Article
- Article
- Robustness of sensory-evoked excitation is increased by inhibitory inputs to distal apical tuft dendrites.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
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7 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Stimulation of a principal whisker yields sparse action potential (AP) spiking in layer 2/3 (L2/3) pyramidal neurons in a cortical column of rat barrel cortex. The low AP rates in pyramidal neurons could be explained by activation of interneurons in L2/3 providing inhibition onto L2/3 pyramidal neurons. L2/3 interneurons classified as local inhibitors based on their axonal projection in the same column were reported to receive strong excitatory input from spiny neurons in L4, which are also the main source of the excitatory input to L2/3 pyramidal neurons. Here, we investigated the remaining synaptic connection in this intracolumnar microcircuit. We found strong and reliable inhibitory synaptic transmission between intracolumnar L2/3 local-inhibitor-to-L2/3 pyramidal neuron pairs [inhibitory postsynaptic potential (IPSP) amplitude -0.88 ± 0.67 mV]. On average, 6.2 ± 2 synaptic contacts were made by L2/3 local inhibitors onto L2/3 pyramidal neurons at 107 ± 64 µm path distance from the pyramidal neuron soma, thus overlapping with the distribution of synaptic contacts from L4 spiny neurons onto L2/3 pyramidal neurons (67 ± 34 µm). Finally, using compartmental simulations, we determined the synaptic conductance per synaptic contact to be 0.77 ± 0.4 nS. We conclude that the synaptic circuit from L4 to L2/3 can provide efficient shunting inhibition that is temporally and spatially aligned with the excitatory input from L4 to L2/3.
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