ArticleCancer causes & control : CCC2015
Mammographic density and breast cancer risk by family history in women of white and Asian ancestry.
Article in Cancer causes & control : CCC, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Breast Density and Risk of Breast Cancer in Asian Women: A Meta-analysis of Observational Studies.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2016Pooled it
- Breastfeeding and breast cancer risk by receptor status--a systematic review and meta-analysis.Annals of oncology : official journal of the European Society for Medical Oncology · 2015Pooled it
- Breast cancers arising in high mammographic density tissue harbor tumor-promoting immune profiles.NPJ breast cancer · 2026Article
- Association between breastfeeding, mammographic density, and breast cancer risk: a review.International breastfeeding journal · 2024Review
- Association between Family History of Breast Cancer and Breast Density in Saudi Premenopausal Women Participating in Mammography Screening.Clinics and practice · 2024Article
- Family history of breast cancer, mammographic breast density and breast cancer risk: Findings from a cohort study of Korean women.Breast (Edinburgh, Scotland) · 2022Article
- Risk factors for breast cancer subtypes among Black women undergoing screening mammography.Breast cancer research and treatment · 2021Article
- Heterogenous Effect of Risk Factors on Breast Cancer across the Breast Density Categories in a Korean Screening Population.Cancers · 2020Article
- The TP53 mutation rate differs in breast cancers that arise in women with high or low mammographic density.NPJ breast cancer · 2020Article
- Predictors of mammographic density among women with a strong family history of breast cancer.BMC cancer · 2019Article
- Interaction Effect Between Breast Density and Reproductive Factors on Breast Cancer Risk in Korean Population.Journal of cancer prevention · 2019Article
- Effects of isoflavones on breast tissue and the thyroid hormone system in humans: a comprehensive safety evaluation.Archives of toxicology · 2018Review
- Family History and Breast Cancer Risk Among Older Women in the Breast Cancer Surveillance Consortium Cohort.JAMA internal medicine · 2018Article
- Breast cancer risk factors and mammographic density among high-risk women in urban China.NPJ breast cancer · 2018Article
- Family History of Breast Cancer, Breast Density, and Breast Cancer Risk in a U.S. Breast Cancer Screening Population.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 8 institutions in 4 countries.
Funding
Abstract
purposeMammographic density, i.e., the radiographic appearance of the breast, is a strong predictor of breast cancer risk. To determine whether the association of breast density with breast cancer is modified by a first-degree family history of breast cancer (FHBC) in women of white and Asian ancestry, we analyzed data from four case-control studies conducted in the USA and Japan.
methodsThe study population included 1,699 breast cancer cases and 2,422 controls, of whom 45% reported white (N = 1,849) and 40% Asian (N = 1,633) ancestry. To standardize mammographic density assessment, a single observer re-read all mammograms using one type of interactive thresholding software. Logistic regression was applied to estimate odds ratios (OR) while adjusting for confounders.
resultsOverall, 496 (12%) of participants reported a FHBC, which was significantly associated with breast cancer risk in the adjusted model (OR 1.51; 95% CI 1.23-1.84). There was a statistically significant interaction on a multiplicative scale between FHBC and continuous percent density (per 10 % density: p = 0.03). The OR per 10% increase in percent density was higher among women with a FHBC (OR 1.30; 95% CI 1.13-1.49) than among those without a FHBC (OR 1.14; 1.09-1.20). This pattern was apparent in whites and Asians. The respective ORs were 1.45 (95% CI 1.17-1.80) versus 1.22 (95% CI 1.14-1.32) in whites, whereas the values in Asians were only 1.24 (95% CI 0.97-1.58) versus 1.09 (95% CI 1.00-1.19).
conclusionsThese findings support the hypothesis that women with a FHBC appear to have a higher risk of breast cancer associated with percent mammographic density than women without a FHBC.
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