Evidence map›Paper›PMID 25761324›Full record

ArticleBlood transfusion = Trasfusione del sangue2015

Use of a haemostatic matrix does not reduce blood loss in minimally invasive total knee arthroplasty.

Pierre-Emmanuel Schwab, Emmanuel Thienpont

2 registry-linked trialsOpen access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood transfusion = Trasfusione del sangue, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02865174 phase4unknown statusnot on this mapstarted 2016, after this paper: background citation

Comparison of Topical Tranexamic Acid and Floseal® on Blood Loss After Total Knee Arthroplasty in Patients With a Thromboembolic Risk

TypeinterventionalSponsorChang Gung Memorial HospitalRan2016 to 2017Enrolled90ConditionsOsteoarthritis, KneeArmsTopical tranexamic acid, Floseal®, Enoxaparin
NCT03328832 phase4completednot on this mapstarted 2017, after this paper: background citation

Comparison of Combined Topical Tranexamic Acid With Floseal® With Intravenous Tranexamic Acid on Blood Loss in Total Knee Arthroplasty

TypeinterventionalSponsorChang Gung Memorial HospitalRan2017 to 2018Enrolled70ConditionsOsteoarthritis, KneeArmsTopical tranexamic acid, Floseal®, rivaroxaban (10mg)
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Use of patient-specific cutting blocks reduces blood loss after total knee arthroplasty.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2017
    Observational
  5. Preoperative haemoglobin cut-off values for the prediction of post-operative transfusion in total knee arthroplasty.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2016
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Pierre-Emmanuel SchwabDepartment of Orthopaedic Surgery, University Hospital Saint Luc-UCL, Brussels, Belgium.
Emmanuel ThienpontDepartment of Orthopaedic Surgery, University Hospital Saint Luc-UCL, Brussels, Belgium.
Cliniques Universitaires Saint-Luc · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBlood loss can increase morbidity and the risk of transfusion after total knee arthroplasty (TKA). This study evaluated the difference in blood loss between minimally invasive TKA performed with and without intra-articular use of a haemostatic matrix (Floseal®). MATERIALS AND

methodsWe retrospectively compared matched pairs in two groups (76 patients in each group): one group received conventional haemostasis (with bovie electrocoagulation), the other group was treated with an intra-articular haemostatic matrix (HM) as an adjunct to electrocoagulation. The outcomes compared were haemoglobin (Hb) and haematocrit levels at days 2 and 4 after surgery as a surrogate for blood loss, transfusion rate, surgical time, preoperative and postoperative range of motion (ROM) at days 21 and 42 and length of stay (LOS) in hospital.

resultsNo differences were observed for Hb levels at day 2 or day 4 between men in the two groups. In women, however, the mean Hb at day 2 was 11.1 g/dL (SD 1.3) for TKA with HM and 12.0 g/dL (SD 0.9) for TKA without HM (p<0.001), while that at day 4 was 10.6 g/dL (SD 1.3) for TKA with HM and 11.4 g/dL (SD 1.2) for TKA without HM (p<0.001). The haematocrit was higher for TKA without HM at day 2 (p=0.001) and day 4 (p=0.008). The transfusion rate for TKA with HM was 2.6% and for TKA without HM 0% (p=0.497), while the mean surgical time was 93 minutes (SD 12) vs 87 minutes (SD 14), respectively (p=0.0055). There were no differences in preoperative or postoperative ROM at days 21 and 42 between the two groups. The LOS was longer for TKA with HM than for TKA without HM (4.5 days and 4 days, respectively, p=0.011) influenced by the longer stay for the transfused patients. DISCUSSION: The present study showed that the use of Floseal had no effect on reducing either visible or hidden blood loss after TKA, as assessed by a drop in Hb or haematocrit and that hidden blood loss was more important in women treated with the HM.

Indexed as

Arthroplasty, Replacement, KneeBlood Loss, SurgicalMinimally Invasive Surgical ProceduresAgedAged, 80 and overFemaleGelatin Sponge, AbsorbableHumansLength of StayMaleMiddle AgedTime FactorsFloSeal Matrix

Identifiers

PMID25761324
PMCPMC4614296
OpenAlexW2115302958

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.