ArticlePflugers Archiv : European journal of physiology1989
Calcium and depolarization dependence of twin-pulse facilitation of synaptic release at nerve terminals of crayfish and frog muscle.
Article in Pflugers Archiv : European journal of physiology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Historical view and physiology demonstration at the NMJ of the crayfish opener muscle.Journal of visualized experiments : JoVE · 2009Article
- Effects of mobile buffers on facilitation: experimental and computational studies.Biophysical journal · 2000Article
- Neurotransmitter release: facilitation and three-dimensional diffusion of intracellular calcium.Bulletin of mathematical biology · 1992Article
- Multiplicative and additive Ca(2+)-dependent components of facilitation at mouse endplates.The Journal of physiology · 1992Article
- Time course of transmitter release calculated from simulations of a calcium diffusion model.Biophysical journal · 1992Article
- Actions of lead on transmitter release at mouse motor nerve terminals.Pflugers Archiv : European journal of physiology · 1991Article
- Evoked phasic release in frog nerve terminals obtained after block of Ca2+ entry by Cd2+.Pflugers Archiv : European journal of physiology · 1991Article
- Inhibition of Ca2+ inflow at nerve terminals of frog muscle blocks facilitation while phasic transmitter release is still considerable.Pflugers Archiv : European journal of physiology · 1990Article
- Shifts in the voltage dependence of synaptic release due to changes in the extracellular calcium concentration at nerve terminals on muscle of crayfish and frogs.Pflugers Archiv : European journal of physiology · 1989Article
- Twin pulse facilitation in dependence on pulse duration and calcium concentration at motor nerve terminals of crayfish and frogs.Pflugers Archiv : European journal of physiology · 1989Article
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1 author at 1 institution in 1 country.
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Abstract
Transmitter quanta were elicited from nerve terminals of crayfish and frog muscle by depolarization pulses through a macro-patch-clamp electrode. The rates of quantal release for twin pulses and their ratio, twin pulse facilitation, Fd, were determined. When the electrode was perfused with normal Cae (13.5 mM for crayfish, 1.8 mM for frog), Fd was low for threshold depolarizations, increased to a maximum at medium depolarizations, decreased when the rate of release due to the first pulse approached saturation, and increased again for larger depolarizations. If under these conditions the superfusion of the muscle outside the electrode was changed from normal to 0 Cab and high Mgb solution, Fd increased. When the Ca concentration around the terminal, Cae, was reduced to levels at which release did not reach the saturation level for large depolarizations, Fd in dependence on depolarization did not show the minimum at higher depolarizations. The amplitude of Fd measured for large, constant depolarization pulses showed a maximum at a Cae below that of the normal solution. The maximum of Fd was much higher if the superfusion of the bath contained 0 Cab and high Mgb than when normal bathing solution was superfused. The maxima of Fd at a low value of Ca inflow are predicted by the "residual Ca" theory of facilitation, if release is influenced by a resting low internal Ca concentration, Cair, and reaches a saturation level for large Ca-inflow. It is also predicted that decreasing Cair (as in low Cab) will increase Fd.
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