ArticlePflugers Archiv : European journal of physiology1989
Calcium dependence of quantal release triggered by graded depolarization pulses to nerve terminals on crayfish and frog muscle.
Article in Pflugers Archiv : European journal of physiology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 61 citations in OpenAlex.
- α-Conotoxin M1 (CTx) blocks αδ binding sites of adult nicotinic receptors while ACh binding at αε sites elicits only small and short quantal synaptic currents.Physiological reports · 2014Article
- Historical view and physiology demonstration at the NMJ of the crayfish opener muscle.Journal of visualized experiments : JoVE · 2009Article
- Anti-ganglioside antibodies alter presynaptic release and calcium influx.Neurobiology of disease · 2007Article
- Effects of mobile buffers on facilitation: experimental and computational studies.Biophysical journal · 2000Article
- Evaluation of the number of agonist molecules needed to activate a ligand-gated channel from the current rising phase.Biophysical journal · 2000Article
- Disorganisation of quantal acetylcholine release by zinc at the Torpedo nerve-electroplate junction.Pflugers Archiv : European journal of physiology · 1996Article
- Dependence on temperature of the effect of dinitrophenol on the release of transmitter quanta at neuromuscular junctions in the mouse diaphragm.British journal of pharmacology · 1996Article
- A two-step model of secretion control in neuroendocrine cells.Pflugers Archiv : European journal of physiology · 1993Article
- Spatial facilitation and depression within one motor nerve terminal of frogs.The Journal of physiology · 1993Article
- Contribution of Ca2+ inflow to quantal, phasic transmitter release from nerve terminals of frog muscle.Pflugers Archiv : European journal of physiology · 1992Article
- Evoked phasic release in frog nerve terminals obtained after block of Ca2+ entry by Cd2+.Pflugers Archiv : European journal of physiology · 1991Article
- Inhibition of Ca2+ inflow at nerve terminals of frog muscle blocks facilitation while phasic transmitter release is still considerable.Pflugers Archiv : European journal of physiology · 1990Article
- Twin pulse facilitation in dependence on pulse duration and calcium concentration at motor nerve terminals of crayfish and frogs.Pflugers Archiv : European journal of physiology · 1989Article
- Calcium and depolarization dependence of twin-pulse facilitation of synaptic release at nerve terminals of crayfish and frog muscle.Pflugers Archiv : European journal of physiology · 1989Article
- Shifts in the voltage dependence of synaptic release due to changes in the extracellular calcium concentration at nerve terminals on muscle of crayfish and frogs.Pflugers Archiv : European journal of physiology · 1989Article
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1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quantal transmitter release was measured in small portions of neuromuscular junctions by means of a perfused macro-patch-clamp electrode. Release was elicited by graded current pulses through the recording electrode (excitation blocked by TTX). On increasing the stimulation current from a threshold amplitude, release rose steeply for several orders of magnitude and finally approached a saturation level of about 10 quanta/pulse. Reduction of the Ca concentration in the perfusate of the electrode, Cae, depressed the saturation level of release relatively little and had practically no effect on the threshold current amplitude, as long as the Ca concentration in the superfusion of the bath, Cab, remained high. When Cab was reduced too, the depression of release was more severe. The dependence of release on Cae was determined for a large range of Cae for saturating depolarization pulses. In crayfish, at 0 Cab, in double-logarithmic release-Cae plots the maximum slope was on average 3.9, and this slope dropped to on average 2.1 in 13.5 mM Cab. In frog, at 0 Cab, the respective double-logarithmic slope was 3.5, while in 1.8 mM Cab this slope declined dramatically, the rate of release decreasing on average only by a factor of 3.8 from 10 mM to 0.02 mM Cae. These results are interpreted by the assumption that the resting Ca concentration in the terminal, Cair, has strong influence on the rate of release due to depolarization pulses in low Cae, and that Cab has control on Cair in the terminal.
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