ArticleHigh altitude medicine & biology2015
The Effects of Portulaca oleracea on Hypoxia-Induced Pulmonary Edema in Mice.
Article in High altitude medicine & biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Dietary methanol extract of purslane (Portulaca oleracea L.) can help reduce the negative impacts of triiodothyronine-induced ascites in broiler chickens.Veterinary research communications · 2025Article
- Probe-based confocal laser endomicroscopy for evaluating high-altitude pulmonary edema in canines.Heliyon · 2023Article
- Exercise performance reduction and preventive measures in highland sports.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- Promising Natural Medicines for the Treatment of High-Altitude Illness.High altitude medicine & biology · 2023Review
- Endothelial cell PHD2-HIF1α-PFKFB3 contributes to right ventricle vascular adaptation in pulmonary hypertension.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Chinese medicinal plants for the potential management of high-altitude pulmonary oedema and pulmonary hypertension.Pharmaceutical biology · 2020Review
- Effect of dietary purslane (Portulaca oleracea L.) leaves powder on growth, immunostimulation, and protection of Nile tilapia, Oreochromis niloticus against Aeromonas hydrophila infection.Fish physiology and biochemistry · 2019Article
- Anti-Asthmatic Effects ofJournal of pharmacopuncture · 2019Review
- A Pharmacological Review onJournal of pharmacopuncture · 2019Review
- Hydro-Ethanolic Extract ofIranian journal of pharmaceutical research : IJPR · 2019Article
- Effects of Portulaca oleracea ethanolic extract on reproductive system of aging female mice.International journal of reproductive biomedicine · 2016Article
- The effect ofIndian journal of pharmacologyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Portulaca oleracea L. (PO) is known as "a vegetable for long life" due to its antioxidant, anti-inflammatory, and other pharmacological activities. However, the protective activity of the ethanol extract of PO (EEPO) against hypoxia-induced pulmonary edema has not been fully investigated. In this study, we exposed mice to a simulated altitude of 7000 meters for 0, 3, 6, 9, and 12 h to observe changes in the water content and transvascular leakage of the mouse lung. It was found that transvascular leakage increased to the maximum in the mouse lung after 6 h exposure to hypobaric hypoxia. Prophylactic administration of EEPO before hypoxic exposure markedly reduced the transvascular leakage and oxidative stress, and inhibited the upregulation of NF-kB in the mouse lung, as compared with the control group. In addition, EEPO significantly reduced the levels of proinflammatory cytokines and cell adhesion molecules in the lungs of mice, as compared with the hypoxia group. Our results show that EEPO can reduce initial transvascular leakage and pulmonary edema under hypobaric hypoxia conditions.
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