ArticleActa crystallographica. Section D, Biological crystallography2015
An intermolecular binding mechanism involving multiple LysM domains mediates carbohydrate recognition by an endopeptidase.
Article in Acta crystallographica. Section D, Biological crystallography, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- A Bait-and-Switch Strategy Links Phenotypes to Genes Coding for Polymer-Degrading Enzymes in Intact Microbiomes.Microbial biotechnology · 2026Article
- Genome-Wide Identification and Expression Analysis of the GH19 Chitinase Gene Family in Sea Island Cotton.Current issues in molecular biology · 2025Article
- Secreted LysM proteins are required for niche competition and full virulence in Pseudomonas savastanoi during host plant infection.PLoS pathogens · 2025Article
- Peptidoglycan NlpC/P60 peptidases in bacterial physiology and host interactions.Cell chemical biology · 2023Review
- Bacterial developmental checkpoint that directly monitors cell surface morphogenesis.Developmental cell · 2022Article
- Improved antimicrobial spectrum of the N-acetylmuramoyl-L-alanine amidase from Latilactobacillus sakei upon LysM domain deletion.World journal of microbiology & biotechnology · 2021Article
- Identification ofToxins · 2020Article
- Homeostatic control of cell wall hydrolysis by the WalRK two-component signaling pathway ineLife · 2019Article
- AProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- A LysM Domain Intervenes in Sequential Protein-Protein and Protein-Peptidoglycan Interactions Important for Spore Coat Assembly inJournal of bacteriology · 2019Article
- The ProtozoanmBio · 2018Article
- LysMD3 is a type II membrane protein without anThe Journal of biological chemistry · 2018Article
- Solution scattering study of the Bacillus subtilis PgdS enzyme involved in poly-γ-glutamic acids degradation.PloS one · 2018Article
- Receptor-mediated chitin perception in legume roots is functionally separable from Nod factor perception.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Chitin oligosaccharide binding to the lysin motif of a novel type of chitinase from the multicellular green alga, Volvox carteri.Plant molecular biology · 2017Article
- An assemblage of Frankia Cluster II strains from California contains the canonical nod genes and also the sulfotransferase gene nodH.BMC genomics · 2016Article
- The pan-genome of Lactobacillus reuteri strains originating from the pig gastrointestinal tract.BMC genomics · 2015Article
- Peptidoglycan Perception in Plants.PLoS pathogens · 2015Review
- Structural Insight into Fungal Cell Wall Recognition by a CVNH Protein with a Single LysM Domain.Structure (London, England : 1993) · 2015Article
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Authors and funding
9 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
LysM domains, which are frequently present as repetitive entities in both bacterial and plant proteins, are known to interact with carbohydrates containing N-acetylglucosamine (GlcNAc) moieties, such as chitin and peptidoglycan. In bacteria, the functional significance of the involvement of multiple LysM domains in substrate binding has so far lacked support from high-resolution structures of ligand-bound complexes. Here, a structural study of the Thermus thermophilus NlpC/P60 endopeptidase containing two LysM domains is presented. The crystal structure and small-angle X-ray scattering solution studies of this endopeptidase revealed the presence of a homodimer. The structure of the two LysM domains co-crystallized with N-acetyl-chitohexaose revealed a new intermolecular binding mode that may explain the differential interaction between LysM domains and short or long chitin oligomers. By combining the structural information with the three-dimensional model of peptidoglycan, a model suggesting how protein dimerization enhances the recognition of peptidoglycan is proposed.
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