ReviewJournal of cellular physiology2015
Can Brown Fat Win the Battle Against White Fat?
Review in Journal of cellular physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Increasing adipocyte number and reducing adipocyte size: the role of retinoids in adipose tissue development and metabolism.Critical reviews in food science and nutrition · 2024Review
- The Role of NADBiomedicines · 2023Review
- Angiotensin(1-7) attenuates visceral adipose tissue expansion and lipogenesis by suppression of endoplasmic reticulum stress via Mas receptor.Nutrition & metabolism · 2022Article
- Contrasting recruitment of skin-associated adipose depots during cold challenge of mouse and human.The Journal of physiology · 2022Article
- Adipocyte Biology from the Perspective of In Vivo Research: Review of Key Transcription Factors.International journal of molecular sciences · 2021Review
- Anti-obesity effect and mechanism of mesenchymal stem cells influence on obese mice.Open life sciences · 2021Article
- The role of Irisin in multiorgan protection.Molecular biology reports · 2021Review
- Genetic Polymorphisms Complicate COVID-19 Therapy: Pivotal Role of HO-1 in Cytokine Storm.Antioxidants (Basel, Switzerland) · 2020Review
- Evaporative cooling provides a major metabolic energy sink.Molecular metabolism · 2019Article
- Looking on the "brite" side exercise-induced browning of white adipose tissue.Pflugers Archiv : European journal of physiology · 2019Review
- Development and initial characterization of a novel ghrelin receptor CRISPR/Cas9 knockout wistar rat model.International journal of obesity (2005) · 2019Article
- Metabolic and genomic adaptations to winter fattening in a primate species, the grey mouse lemur (Microcebus murinus).International journal of obesity (2005) · 2018Article
- Exercise Induces White Adipose Tissue Browning Across the Weight Spectrum in Humans.Frontiers in physiology · 2018Article
- Dielectric properties measurements of brown and white adipose tissue in rats from 0.5 to 10 GHz.Biomedical physics & engineering express · 2016Article
- LncRNAs in Stem Cells.Stem cells international · 2016Review
- Lecithin:Cholesterol Acyltransferase (LCAT) Deficiency Promotes Differentiation of Satellite Cells to Brown Adipocytes in a Cholesterol-dependent Manner.The Journal of biological chemistry · 2015Article
- Two-Pore Channels: Lessons from Mutant Mouse Models.Messenger (Los Angeles, Calif. : Print) · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
A rapid growth in the overweight and obese population in the last few decades suggest that the current diet, exercise, awareness or drug strategies are still not effectively restraining the obesity epidemic. Obesity results from increased energy intake, and the body's energy balance shifts towards energy abundance. Therefore, current research is focused on developing new strategies aimed at increasing energy expenditure. As a result, brown adipose tissue (BAT) is receiving tremendous attention since the major function of BAT is to dissipate energy as heat. For example, mouse models that have increased BAT activity or increased numbers of brown-like adipocytes within the white adipose tissue (WAT) are lean and protected from obesity. Alternatively, mouse models that lack BAT activity are more susceptible to age and diet-induced obesity. However, a significant loss of BAT mass during the natural growth process in humans has created enormous challenges in effectively utilizing this tissue to increase energy expenditure. New strategies are primarily focused on expanding the BAT mass and/or activating the existing BAT. In this regard, recent finding that expression of early B cell factor-2 (Ebf2) reprograms the white pre-adipocytes into brown adipocytes is a significant break-through in developing BAT-mediated strategies to treat obesity. Here we review the major biological functions of WAT and BAT, which play critical but opposing roles in the energy spectrum, energy storage versus energy expenditure, and we evaluate whether activation and/or expansion of BAT is practically achievable to treat obesity in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.