ArticlePLoS genetics2015
Cis-regulatory mechanisms for robust olfactory sensory neuron class-restricted odorant receptor gene expression in Drosophila.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- New dimensions in the molecular genetics of insect chemoreception.Trends in genetics : TIG · 2025Review
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- Impact of elevated COScientific reports · 2025Article
- Hedgehog-mediated gut-taste neuron axis controls sweet perception in Drosophila.Nature communications · 2022Article
- Non-canonical odor coding in the mosquito.Cell · 2022Article
- Comparative RNA-Seq Analyses ofGenes · 2021Article
- A combinatorial cis-regulatory logic restricts color-sensing Rhodopsins to specific photoreceptor subsets in Drosophila.PLoS genetics · 2021Article
- Stress and odorant receptor feedback during a critical period after hatching regulates olfactory sensory neuron differentiation in Drosophila.PLoS biology · 2021Article
- Olfactory Receptor Gene Regulation in Insects: Multiple Mechanisms for Singular Expression.Frontiers in neuroscience · 2021Review
- Odor response adaptation in Drosophila-a continuous individualization process.Cell and tissue research · 2021Article
- Differential Transcriptome Analysis Reveals Genes Related to Low- and High-Temperature Stress in the Fall Armyworm,Frontiers in physiology · 2021Article
- A low affinityeLife · 2020Article
- Article
- Evolution, developmental expression and function of odorant receptors in insects.The Journal of experimental biology · 2020Review
- Sensory neuron lineage mapping and manipulation in the Drosophila olfactory system.Nature communications · 2019Article
- Thermodynamic model of gene regulation for the Or59b olfactory receptor in Drosophila.PLoS computational biology · 2019Article
- Recent Advances in Behavioral (Epi)Genetics in Eusocial Insects.Annual review of genetics · 2018Review
- Computational genome-wide survey of odorant receptors from two solitary bees Dufourea novaeangliae (Hymenoptera: Halictidae) and Habropoda laboriosa (Hymenoptera: Apidae).Scientific reports · 2017Article
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Authors and funding
2 authors.
Funding
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Abstract
Odor perception requires that each olfactory sensory neuron (OSN) class continuously express a single odorant receptor (OR) regardless of changes in the environment. However, little is known about the control of the robust, class-specific OR expression involved. Here, we investigate the cis-regulatory mechanisms and components that generate robust and OSN class-specific OR expression in Drosophila. Our results demonstrate that the spatial restriction of expression to a single OSN class is directed by clusters of transcription-factor DNA binding motifs. Our dissection of motif clusters of differing complexity demonstrates that structural components such as motif overlap and motif order integrate transcription factor combinations and chromatin status to form a spatially restricted pattern. We further demonstrate that changes in metabolism or temperature perturb the function of complex clusters. We show that the cooperative regulation between motifs around and within the cluster generates robust, class-specific OR expression.
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